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通过微核试验评估酵母中诱导非整倍体的化学物质。

Aneuploidy-inducing chemicals in yeast evaluated by the micronucleus test.

作者信息

Basler A

出版信息

Mutat Res. 1986 May;174(1):11-3. doi: 10.1016/0165-7992(86)90070-9.

DOI:10.1016/0165-7992(86)90070-9
PMID:3517637
Abstract

Chinese hamsters were exposed to acetone, methyl ethyl ketone, ethyl acetate and 2-methoxy ethyl acetate, known to be strong inducers of aneuploidy in the yeast Saccharomyces cerevisiae. All solvents yielded negative results in the micronucleus test, whereas the vinca alkaloid vindesine--used as a positive control substance--proved to act as a spindle poison in mammals in vivo.

摘要

将中国仓鼠暴露于丙酮、甲乙酮、乙酸乙酯和乙酸2-甲氧基乙酯中，已知这些物质是酿酒酵母中非整倍体的强诱导剂。所有溶剂在微核试验中均产生阴性结果，而用作阳性对照物质的长春花生物碱长春地辛在体内对哺乳动物起到纺锤体毒素的作用。

相似文献

1
Aneuploidy-inducing chemicals in yeast evaluated by the micronucleus test.通过微核试验评估酵母中诱导非整倍体的化学物质。
Mutat Res. 1986 May;174(1):11-3. doi: 10.1016/0165-7992(86)90070-9.
2
Acetone, methyl ethyl ketone, ethyl acetate, acetonitrile and other polar aprotic solvents are strong inducers of aneuploidy in Saccharomyces cerevisiae.丙酮、甲乙酮、乙酸乙酯、乙腈和其他极性非质子溶剂是酿酒酵母中非整倍体的强诱导剂。
Mutat Res. 1985 May;149(3):339-51. doi: 10.1016/0027-5107(85)90150-2.
3
Effects of chemical combinations on the induction of aneuploidy in Saccharomyces cerevisiae.
Mutat Res. 1987 Jan;187(1):21-30. doi: 10.1016/0165-1218(87)90072-3.
4
Investigations of aneuploidy-inducing chemical combinations in Saccharomyces cerevisiae.
Mutat Res. 1988 Oct;201(2):413-21. doi: 10.1016/0027-5107(88)90028-0.
5
Aprotic polar solvents inducing chromosomal malsegregation in yeast interfere with the assembly of porcine brain tubulin in vitro.在酵母中诱导染色体错分离的非质子极性溶剂在体外会干扰猪脑微管蛋白的组装。
Mutat Res. 1985 May;149(3):333-8. doi: 10.1016/0027-5107(85)90149-6.
6
The influence of solvent stress on MMS-induced genetic change in Saccharomyces cerevisiae.溶剂胁迫对酿酒酵母中MMS诱导的基因变化的影响。
Mutat Res. 1991 Sep-Oct;250(1-2):239-49. doi: 10.1016/0027-5107(91)90181-m.
7
Reevaluation of the 9 compounds reported conclusive positive in yeast Saccharomyces cerevisiae aneuploidy test systems by the Gene-Tox Program using strain D61.M of Saccharomyces cerevisiae.通过基因毒性计划，使用酿酒酵母菌株D61.M对酿酒酵母非整倍体测试系统中报告为确定性阳性的9种化合物进行重新评估。
Mutat Res. 1991 Jun;260(2):165-80. doi: 10.1016/0165-1218(91)90005-7.
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Aneuploidy induced by nocodazole or ethyl acetate is suppressed by dimethyl sulfoxide.
Mutat Res. 1987 Jan;187(1):31-5. doi: 10.1016/0165-1218(87)90073-5.
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Induction of aneuploidy by oncodazole (nocodazole), an anti-tubulin agent, and acetone.
Mutat Res. 1984 Sep;141(1):15-8. doi: 10.1016/0165-7992(84)90030-7.
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The detection of aneugens using yeasts and cultured mammalian cells.使用酵母和培养的哺乳动物细胞检测非整倍体原。
Prog Clin Biol Res. 1990;340B:247-66.

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