多囊卵巢综合征中生物活性和免疫反应性催乳素的分泌动力学

Secretory dynamics of bioactive and immunoreactive prolactin in polycystic ovary syndrome.

作者信息

Anderson R E, Ben-Rafael Z, Flickinger G L, Meloni F, Barnes R B, Rosen G F, Lobo R A

机构信息

Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.

出版信息

Fertil Steril. 1988 Feb;49(2):239-43. doi: 10.1016/s0015-0282(16)59709-x.

DOI:10.1016/s0015-0282(16)59709-x

PMID:3276562

Abstract

To further investigate prolactin (PRL) secretion in polycystic ovary syndrome (PCO), the authors evaluated immunoreactive (immuno) and bioactive (bio) PRL levels in the basal state and in response to provocative testing with intravenous dopamine (DA), metoclopramide (MCP), and gonadotropin-releasing hormone (GnRH), before and after disulfiram. Basal measurements of immuno-PRL, bio-PRL, and the ratio of bio/immuno-PRL were similar in PCO and controls. The immuno-PRL decrement after DA was greater than that of bio-PRL in both groups (P less than 0.05). After MCP, immuno-PRL increased more than bio-PRL in PCO (P less than 0.01), and this immuno-PRL increment was greater than that of controls (P less than 0.05). Bio-PRL and immuno-PRL increased after GnRH in PCO, but not controls, and these responses were inhibited by disulfiram. These data confirm PRL hypersecretion in some women with PCO, which is better expressed by immunoreactivity than bioactivity. Given the assay systems and patients studied, bioactivity

摘要

为了进一步研究多囊卵巢综合征（PCO）患者的催乳素（PRL）分泌情况，作者评估了双硫仑治疗前后，基础状态下以及静脉注射多巴胺（DA）、甲氧氯普胺（MCP）和促性腺激素释放激素（GnRH）激发试验后的免疫反应性（免疫）和生物活性（生物）PRL水平。PCO患者和对照组的基础免疫PRL、生物PRL以及生物/免疫PRL比值相似。两组中，DA注射后免疫PRL的下降幅度均大于生物PRL（P<0.05）。MCP注射后，PCO患者免疫PRL的升高幅度大于生物PRL（P<0.01），且该免疫PRL升高幅度大于对照组（P<0.05）。GnRH注射后，PCO患者的生物PRL和免疫PRL升高，而对照组无此变化，且这些反应被双硫仑抑制。这些数据证实了部分PCO女性存在PRL分泌过多，免疫反应性比生物活性更能体现这一情况。考虑到所研究的检测系统和患者，生物活性