Surlin Petra, Gheorghe Dorin Nicolae, Popescu Dora Maria, Martu Alexandra Maria, Solomon Sorina, Roman Alexandra, Lazar Luminita, Stratul Stefan Ioan, Rusu Darian, Foia Liliana, Boldeanu Mihail Virgil, Boldeanu Lidia, Danilescu Monica, Rogoveanu Ion
Department of Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Periodontology, Faculty of Dental Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
Exp Ther Med. 2020 Sep;20(3):2381-2386. doi: 10.3892/etm.2020.8906. Epub 2020 Jun 18.
The study assessed whether the increased production of interleukin-1α (IL-1α) and interleukin-1β (IL-1β), as a result of chronic hepatic inflammation, could be the expression of the negative impact on periodontal disease. The study included chronic periodontitis patients who were systemically healthy, chronic periodontitis patients suffering from chronic hepatitis C, as well as control patients, being systemically and periodontally healthy. After periodontal examination and the assessment of certain periodontal parameters, gingival crevicular fluid was collected from all participating patients. By using the enzyme-linked immunosorbent assay method, a quantitative assessment of IL-1α and IL-1β levels was possible. The immunologic results were correlated to the clinical periodontal data. The gingival fluid levels of cytokines were higher for periodontitis patients with chronic hepatitis C than for the systemically healthy periodontitis patients (1.8-fold higher for IL-1α and 2.1-fold higher for IL-1β). In addition, the gingival fluid cytokine levels were significantly higher for the periodontal patients (with/without chronic hepatitis C) than for the control group. Positive correlations were found between gingival fluid IL-1α and IL-1β levels and certain clinical periodontal parameters or the age of the viral hepatitis C diagnosis, in periodontitis patients with chronic hepatitis C. The chronic hepatic inflammation may have an important additional negative impact on the periodontal status, as both inflammatory reactions seem to be promoted by common pro-inflammatory cytokines.
该研究评估了由于慢性肝脏炎症导致的白细胞介素-1α（IL-1α）和白细胞介素-1β（IL-1β）产量增加是否可能是对牙周疾病产生负面影响的表现。该研究纳入了全身健康的慢性牙周炎患者、患有慢性丙型肝炎的慢性牙周炎患者以及全身和牙周均健康的对照患者。在进行牙周检查并评估某些牙周参数后，从所有参与研究的患者中收集龈沟液。通过使用酶联免疫吸附测定法，可以对IL-1α和IL-1β水平进行定量评估。将免疫学结果与临床牙周数据相关联。患有慢性丙型肝炎的牙周炎患者的龈沟液细胞因子水平高于全身健康的牙周炎患者（IL-1α高1.8倍，IL-1β高2.1倍）。此外，牙周炎患者（无论是否患有慢性丙型肝炎）的龈沟液细胞因子水平均显著高于对照组。在患有慢性丙型肝炎的牙周炎患者中，发现龈沟液IL-1α和IL-1β水平与某些临床牙周参数或丙型病毒性肝炎诊断年龄之间存在正相关。慢性肝脏炎症可能对牙周状况产生重要的额外负面影响，因为这两种炎症反应似乎都由共同的促炎细胞因子所促进。
