一名产前暴露于寨卡病毒的患者出现单侧牵牛花盘状异常。
Unilateral morning glory disc anomaly in a patient with prenatal Zika virus exposure.
作者信息
Muns Sofía M, González Mónica P, Villegas Victor M, de la Vega Gabriela, Ventura Camila V, Berrocal Audina M
机构信息
Department of Ophthalmology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936-5067 USA.
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
出版信息
Int J Retina Vitreous. 2020 Aug 1;6:36. doi: 10.1186/s40942-020-00240-1. eCollection 2020.
BACKGROUND
To report a case of morning glory disc anomaly (MGDA) in a pediatric patient with prenatal Zika virus (ZIKV) exposure.
CASE PRESENTATION
A 3-year-old male with prenatal exposure to ZIKV, confirmed by real-time polymerase chain reaction testing during the second trimester of pregnancy, was evaluated due to visual loss. Physical examination was remarkable for unilateral MGDA. Neuroimaging showed a base of skull encephalocele through the floor of the sella and callosal dysgenesis.
CONCLUSIONS
This is the first report to suggest an association between prenatal ZIKV exposure and MGDA. Prenatal ZIKV exposure may be associated to a wider pathologic spectrum than previously reported.
背景
报告1例产前暴露于寨卡病毒（ZIKV）的儿科患者出现牵牛花盘状异常（MGDA）的病例。
病例介绍
一名3岁男性，产前暴露于ZIKV，在妊娠中期通过实时聚合酶链反应检测确诊，因视力丧失接受评估。体格检查发现单侧MGDA明显。神经影像学检查显示通过蝶鞍底部的颅底脑膨出和胼胝体发育不全。
结论
这是首份提示产前ZIKV暴露与MGDA之间存在关联的报告。产前ZIKV暴露可能与比先前报道更广泛的病理谱相关。
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