与疑似先天性寨卡综合征相关的小头畸形婴儿的视觉系统。
The visual system in infants with microcephaly related to presumed congenital Zika syndrome.
作者信息
Verçosa Islane, Carneiro Paula, Verçosa Reno, Girão Renata, Ribeiro Erlane M, Pessoa Andre, Almeida Nadia G, Verçosa Paloma, Tartarella Marcia B
机构信息
CAVIVER NGO Clinic, Fortaleza, Ceara, Brazil.
Albert Sabin Pediatric Hospital, Fortaleza, Ceara, Brazil.
出版信息
J AAPOS. 2017 Aug;21(4):300-304.e1. doi: 10.1016/j.jaapos.2017.05.024. Epub 2017 Jun 23.
PURPOSE
To describe and analyze ocular features in infants with microcephaly due to presumed congenital Zika syndrome.
METHODS
Ophthalmologic evaluation, including indirect ophthalmoscopy and eye fundus imaging, visual acuity testing with Teller Acuity Cards, and strabismus assessment were performed in infants with microcephaly at a nongovernmental organization clinic for visually disabled children.
RESULTS
A total of 70 infants with microcephaly were referred to the clinic. Of these, 25 (mean age, 3 months; 14 males) had ophthalmologic changes: 18 (26%) had intraocular abnormalities, including macular chorioretinal atrophy, mottled retinal pigment epithelium and optic nerve pallor; 7 patients (10%) had strabismus or nystagmus without intraocular abnormalities. Visual acuity was below normal range in all 11 infants tested.
CONCLUSIONS
Ophthalmologic abnormalities occurred in 36% of the patients. Macular circumscribed chorioretinal atrophy, focal mottled retinal pigment epithelium, optic nerve pallor, early-onset strabismus, nystagmus and low visual acuity were common ophthalmological features in infants with microcephaly due to presumed congenital Zika syndrome.
目的
描述并分析因疑似先天性寨卡综合征导致小头畸形的婴儿的眼部特征。
方法
在一家针对视障儿童的非政府组织诊所，对小头畸形婴儿进行眼科评估，包括间接检眼镜检查和眼底成像、使用泰勒视力卡片进行视力测试以及斜视评估。
结果
共有70名小头畸形婴儿被转诊至该诊所。其中，25名（平均年龄3个月；14名男性）有眼科改变：18名（26%）有眼内异常，包括黄斑脉络膜视网膜萎缩、斑驳的视网膜色素上皮和视神经苍白；7名患者（10%）有斜视或眼球震颤但无眼内异常。在所有11名接受测试的婴儿中，视力均低于正常范围。
结论
36%的患者出现眼科异常。黄斑局限性脉络膜视网膜萎缩、局灶性斑驳的视网膜色素上皮、视神经苍白、早发性斜视、眼球震颤和低视力是因疑似先天性寨卡综合征导致小头畸形的婴儿常见的眼科特征。
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