Li Sijie, Han Cong, Asmaro Karam, Quan Shanyi, Li Ming, Ren Changhong, Zhang Jun, Zhao Wenbo, Xu Jiali, Liu Zhiwen, Zhang Peng, Zhu Lingling, Ding Yuchuan, Wang Kai, Ji Xunming, Duan Lian
1Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
2Department of Neurosurgery, Fifth Medical Center of PLA General Hospital, Beijing, China.
Aging Dis. 2020 Jul 23;11(4):820-827. doi: 10.14336/AD.2019.0605. eCollection 2020 Jul.
Remote ischemic conditioning (RIC) confers protection on major organs from hypoxic/ischemic injuries; however, its impacts on attention network function and blood oxygen levels in unacclimatized adults exposed to high altitudes have yet to be elucidated. In this study, we recruited 120 healthy male volunteers, of which one was exposed to high altitude and the other was exposed to low altitude. The two cohorts were further divided into RIC and sham control groups. The attentional network test (ANT) was performed to evaluate cognitive function before and after RIC treatment. Other outcomes such as heart rate, blood pressure, blood oxygen saturation, cerebral tissue oxygenation index (CTOI), and cerebrovascular hemodynamic indices were also evaluated. Prior to RIC treatment, there were no significant differences in orienting or executive function between the treatment and control arms of either cohort. Alerting function was significantly lower in the high-altitude cohort than in the low-altitude cohort. There were significant reductions in both blood oxygen and CTOI in the high-altitude cohort relative to the low-altitude cohort, while the pulse index (PI) of the former cohort was significantly increased. After RIC treatment, there was a significant difference in alerting function between the high-altitude RIC group and its associated control. The CTOI of the treatment group increased from 60.39±3.40% to 62.78±4.40%, and blood oxygenation also improved. Furthermore, this group showed a significant reduction in its PI. Exposure to high-altitude environments had a significant impact on alerting function, blood oxygen, CTOI, and PI. RIC ameliorated changes in attentional function, as well as blood oxygen and CTOI, suggesting that it potentially alters cerebrovascular compliance upon exposure to high altitude.
远程缺血预处理（RIC）可保护主要器官免受缺氧/缺血性损伤；然而，其对未适应高原环境的成年人注意力网络功能和血氧水平的影响尚待阐明。在本研究中，我们招募了120名健康男性志愿者，其中一组暴露于高原环境，另一组暴露于低海拔环境。这两组又进一步分为RIC组和假手术对照组。在RIC治疗前后进行注意力网络测试（ANT）以评估认知功能。还评估了其他指标，如心率、血压、血氧饱和度、脑组织氧合指数（CTOI）和脑血管血流动力学指标。在RIC治疗前，两组治疗组和对照组在定向或执行功能方面均无显著差异。高海拔组的警觉功能显著低于低海拔组。与低海拔组相比，高海拔组的血氧和CTOI均显著降低，而前一组的脉搏指数（PI）显著升高。RIC治疗后，高海拔RIC组与其相关对照组在警觉功能方面存在显著差异。治疗组的CTOI从60.39±3.40%增加到62.78±4.40%，血氧也有所改善。此外，该组的PI显著降低。暴露于高原环境对警觉功能、血氧、CTOI和PI有显著影响。RIC改善了注意力功能以及血氧和CTOI的变化，表明其可能在暴露于高原时改变脑血管顺应性。
