Malik Sadaf Jabeen, Melwani Rekha, Bano Farhat, Suria Bilal, Sial Ihsanullah, Tasneem Bushra, Ariff Madiha
Surgery, Al-Tibri Medical College, Isra University, Karachi, PAK.
Surgery, Shaheed Muhtarama Benazir Bhutto Medical College, Karachi, PAK.
Cureus. 2020 Jul 1;12(7):e8938. doi: 10.7759/cureus.8938.
Objective The aim of this study is to determine the frequency and risk factors for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (Anti-HCV) in a preoperative screening of patients admitted at the surgical unit of Al-Tibri Medical College and Hospital and Lyari General Hospital, Karachi. Materials and methods This study was conducted at the surgical units of Al-Tibri Medical College Hospital and Lyari General Hospital, Karachi. This study was conducted for six months from 30th June 2017 to 31st December 2017. This observational study was performed using a non-probability convenient sampling technique. All patients who were undergoing elective and emergency surgical procedure were selected for the study and screened for HBsAg and anti-HCV by immunochromatographic test (ICT) method at the hospital laboratory. The risk factors identified as parenteral injections, past surgical procedure, blood transfusion, etc. along with demographic data as age, gender, and district residential status were recorded on a specially designed proforma. Data were analyzed using Statistical Package for the Social Sciences (SPSS) version 23. Descriptive statistics were applied, and the qualitative data were expressed as the mean and standard deviation. Results Among a total of 360 patients included in the study, 63 (21.38%) were found with anti-HCV positive, and 14 (3.88%) were HBsAg positive with none of the patients found to have co-infection. The male-to-female ratio was 2.3:1. The mean age of patients was 32.34±4.3 years. The age range affected commonly in the study population was 21-30 years, 24(31%). The commonest risk factor for transmission of viral infection was parenteral injection abuser 31(40.2%), followed by surgical procedure 13(18.1%), blood transfusion 10(12.9%), and barber shave 7(9.1%). Conclusion It was predicted in our study that hepatitis C was more common in patients screened preoperatively for surgery. However, the most frequent risk factor in these patients was parenteral abuse history. The preoperative screening is an important investigative tool for the identification of silent cases in the community for preventive measures adoption and treatment for silent carriers.
目的 本研究旨在确定在卡拉奇阿尔 - 提卜里医学院医院和利亚里综合医院外科病房收治患者的术前筛查中，乙型肝炎表面抗原（HBsAg）和抗丙型肝炎病毒（抗 - HCV）的检出率及危险因素。材料与方法 本研究在卡拉奇阿尔 - 提卜里医学院医院和利亚里综合医院的外科病房进行。研究从2017年6月30日至2017年12月31日，为期6个月。本观察性研究采用非概率方便抽样技术。所有接受择期和急诊外科手术的患者被选入研究，并在医院实验室通过免疫层析试验（ICT）方法筛查HBsAg和抗 - HCV。将确定的危险因素如非肠道注射、既往外科手术、输血等以及人口统计学数据如年龄、性别和地区居住状况记录在专门设计的表格上。数据使用社会科学统计软件包（SPSS）23版进行分析。应用描述性统计，定性数据以均值和标准差表示。结果 在纳入研究的总共360名患者中，发现63例（21.38%）抗 - HCV阳性，14例（3.88%）HBsAg阳性，且未发现患者合并感染。男女比例为2.3:1。患者的平均年龄为32.34±4.3岁。研究人群中最常受影响的年龄范围是21 - 30岁，共24例（31%）。病毒感染传播的最常见危险因素是非肠道注射滥用者31例（40.2%），其次是外科手术13例（18.1%）、输血10例（12.9%）和理发店剃须7例（9.1%）。结论 我们的研究预测，丙型肝炎在术前接受手术筛查的患者中更为常见。然而，这些患者中最常见的危险因素是有非肠道滥用史。术前筛查是识别社区中无症状病例以采取预防措施和治疗无症状携带者的重要调查工具。
