Lazaridou Asimina, Paschali Myrella, Schreiber Kristin, Galenkamp Laura, Berry Michael, Paschalis Theodoros, Napadow Vitaly, Edwards Robert R
Department of Anesthesiology, Harvard Medical School, Brigham and Women's Hospital, Chestnut Hill, MA, USA.
Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.
Pain Rep. 2020 Jul 27;5(4):e832. doi: 10.1097/PR9.0000000000000832. eCollection 2020 Jul-Aug.
Fibromyalgia (FM) is a condition marked by widespread chronic pain and an array of somatic and psychological symptoms. The primary objective of this study was to explore daily associations between physical activity and pain intensity among a sample of women with FM and the potential moderation of this association by pain catastrophizing.
Women with FM (N = 107) completed questionnaires assessing pain, FM symptoms, and psychological measures and were then asked to report their levels of daily pain catastrophizing, physical activity, and pain intensity once per day for a period of 1 week using daily electronic diary-based tracking. In addition, objective measures of physical activity were collected using an activity tracker (Fitbit Flex), which measured step counts. Daily self-report physical activity was used as the independent variable and pain intensity (Brief Pain Inventory) was the outcome, whereas daily pain catastrophizing was tested in the model as the potential moderator.
Moderation analyses demonstrated associations between physical activity and pain intensity, which were moderated by patient's level of catastrophizing (B = 0.003, SE = 0.001, < 0.05), with patients scoring higher in daily catastrophizing showing a relatively stronger link between higher day-to-day physical activity and increased daily FM pain. Significant associations were observed between pain catastrophizing, pain intensity, and Fitbit Flex step count ( < 0.05).
Our findings suggest that increases in daily physical activity is associated with more self-reported pain intensity in women with FM pain, particularly among those with higher levels of pain catastrophizing.
纤维肌痛（FM）是一种以广泛的慢性疼痛以及一系列躯体和心理症状为特征的病症。本研究的主要目的是探讨患有纤维肌痛的女性样本中身体活动与疼痛强度之间的日常关联，以及疼痛灾难化对这种关联的潜在调节作用。
患有纤维肌痛的女性（N = 107）完成了评估疼痛、纤维肌痛症状和心理指标的问卷，然后被要求使用基于电子日记的每日追踪，在为期1周的时间里每天报告一次她们的日常疼痛灾难化程度、身体活动水平和疼痛强度。此外，使用活动追踪器（Fitbit Flex）收集身体活动的客观指标，该追踪器测量步数。将每日自我报告的身体活动作为自变量，疼痛强度（简短疼痛量表）作为结果，而将每日疼痛灾难化程度作为潜在调节因素在模型中进行检验。
调节分析表明身体活动与疼痛强度之间存在关联，这种关联受到患者灾难化程度的调节（B = 0.003，标准误 = 0.001，P < 0.05），日常灾难化得分较高的患者显示出较高的日常身体活动与每日纤维肌痛疼痛增加之间的联系相对更强。在疼痛灾难化、疼痛强度和Fitbit Flex步数之间观察到显著关联（P < 0.05）。
我们的研究结果表明，日常身体活动的增加与患有纤维肌痛疼痛的女性更多的自我报告疼痛强度相关，特别是在那些疼痛灾难化程度较高的女性中。
