对法国神经性厌食症限制型患者样本的认知障碍评估：出现了两种不同的特征，在功能受损和精神病理症状方面存在差异。
Evaluation of cognitive impairment in a French sample of patients with restrictive anorexia nervosa: two distinct profiles emerged with differences in impaired functions and psychopathological symptoms.
作者信息
Cholet J, Rousselet M, Donnio Y, Burlot M, Pere M, Lambert S, Rocher B, Chirio-Espitalier M, Eyzop E, Grall-Bronnec M
机构信息
Clinical Investigation Unit BALANCED "BehaviorAL AddictioNs and ComplEx Mood Disorders", Addictology and Psychiatry Department, University Hospital of Nantes, 85 Rue Saint Jacques, 44093, Nantes Cedex 1, France.
U1246 SPHERE "methodS in Patient-Centered Outcomes and HEalth ResEarch", INSERM, University of Nantes and Tours, 22 Boulevard Benoni-Goullin, 44200, Nantes, France.
出版信息
Eat Weight Disord. 2021 Jun;26(5):1559-1570. doi: 10.1007/s40519-020-00981-w. Epub 2020 Aug 7.
PURPOSE
The cognitive profiles of patients suffering from anorexia nervosa (AN) are currently explored as potential facilitating and/or maintenance factors. Specific data in restrictive AN (AN-R) remain contradictory. This study focused on women with AN-R to evaluate their cognitive functions to develop a more specific cognitive remediation program.
METHODS
Female patients older than 15 years who were suffering from AN-R were recruited in a specialized unit for eating disorder management. Female healthy control (HC) participants were recruited who were matched with AN patients on age. All participants completed a cognitive evaluation (premorbid intelligence quotient (IQ), planning, information processing speed, cognitive flexibility) and a clinical evaluation (impulsivity, anxiety, depression).
RESULTS
A total of 122 participants were included. Patients suffering from AN-R had significant impairment in information processing speed and planning. Patients exhibited significantly better cognitive flexibility than did the HC group when adjustments were made for other cognitive functions and impulsivity. Two distinct subgroups of patients were identified. The first subgroup had more marked cognitive impairment and fewer psychopathological symptoms than did the second subgroup of patients and the HC group.
CONCLUSION
Our results highlight cognitive impairment in patients with AN who had normal premorbid IQ. Two distinct profiles emerge. In clinical practice, these results open up perspectives for the development of more specific cognitive remediation programs (one specific program for cold cognitions and another specific program targeting emotions and hot cognitions). These results warrant confirmation by larger studies with a more specific evaluation of the impact of emotional status. Trial registration NTC02381639, Date of registration. March 6, 2015.
目的
目前正在探究神经性厌食症（AN）患者的认知概况，将其作为潜在的促进和/或维持因素。限制型神经性厌食症（AN-R）的具体数据仍存在矛盾。本研究聚焦于AN-R女性患者，以评估她们的认知功能，从而制定更具针对性的认知康复计划。
方法
在一个专门管理饮食失调的科室招募了年龄超过15岁的AN-R女性患者。招募了年龄与AN患者匹配的健康女性对照（HC）参与者。所有参与者均完成了一项认知评估（病前智商（IQ）、计划能力、信息处理速度、认知灵活性）和一项临床评估（冲动性、焦虑、抑郁）。
结果
共纳入122名参与者。AN-R患者在信息处理速度和计划能力方面存在显著损害。在对其他认知功能和冲动性进行调整后，患者表现出比HC组显著更好的认知灵活性。识别出了两个不同的患者亚组。与第二亚组患者和HC组相比，第一亚组的认知损害更明显，心理病理症状更少。
结论
我们的结果突出了病前IQ正常的AN患者存在认知损害。出现了两种不同的概况。在临床实践中，这些结果为制定更具针对性的认知康复计划（一个针对冷认知的特定计划和另一个针对情绪及热认知的特定计划）开辟了前景。这些结果有待更大规模的研究进行确认，并对情绪状态的影响进行更具体的评估。试验注册编号NTC02381639，注册日期：2015年3月6日。
Zotero 插件