Epoxygenase-Derived Epoxyeicosatrienoic Acid Mediators Are Associated With Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, and Fibrosis.
作者信息
Arvind Ashwini, Osganian Stephanie A, Sjoquist Julia A, Corey Kathleen E, Simon Tracey G
机构信息
Harvard Medical School, Boston, Massachusetts; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Boston, Massachusetts.
Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Boston, Massachusetts.
出版信息
Gastroenterology. 2020 Dec;159(6):2232-2234.e4. doi: 10.1053/j.gastro.2020.08.001. Epub 2020 Aug 5.
Abstract
摘要
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本文引用的文献
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Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor deficient mice by an increase in PGC1α-HO-1-PGC1α-mitochondrial signaling.环氧二十碳三烯酸干预通过增加 PGC1α-HO-1-PGC1α-线粒体信号改善瘦素受体缺陷型小鼠的非酒精性脂肪性肝病。
Exp Cell Res. 2019 Jul 15;380(2):180-187. doi: 10.1016/j.yexcr.2019.04.029. Epub 2019 Apr 27.
2
Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.细胞色素P450环氧合酶衍生的环氧二十碳三烯酸对小鼠和人类的胰岛素敏感性有影响。
Diabetologia. 2017 Jun;60(6):1066-1075. doi: 10.1007/s00125-017-4260-0. Epub 2017 Mar 28.
3
Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.非酒精性脂肪性肝炎中细胞色素P450环氧二十碳三烯酸途径的特征
Prostaglandins Other Lipid Mediat. 2016 Sep;125:19-29. doi: 10.1016/j.prostaglandins.2016.07.002. Epub 2016 Jul 9.
4
Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study.细胞色素P450衍生的环氧二十碳三烯酸与人类冠状动脉疾病：一项靶向代谢组学研究
J Lipid Res. 2016 Jan;57(1):109-19. doi: 10.1194/jlr.M061697. Epub 2015 Nov 10.
5
Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis.多不饱和脂肪酸代谢产物作为非酒精性脂肪性肝炎无创诊断的新型脂质组学生物标志物。
J Lipid Res. 2015 Jan;56(1):185-92. doi: 10.1194/jlr.P055640. Epub 2014 Nov 17.
6
The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease.细胞色素 P450 加单氧酶环氧合酶途径调节脂肪性肝病中的肝炎症反应。
PLoS One. 2014 Oct 13;9(10):e110162. doi: 10.1371/journal.pone.0110162. eCollection 2014.
7
Epoxyeicosanoids promote organ and tissue regeneration.环氧二十碳烯酸类促进器官和组织再生。
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13528-33. doi: 10.1073/pnas.1311565110. Epub 2013 Jul 29.
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Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.人细胞色素 P450 加单氧酶环氧合酶的内皮表达降低血压并减轻小鼠高血压引起的肾脏损伤。
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