Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450052, China.
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing City, 102206, China.
Biomed Pharmacother. 2020 Sep;129:110475. doi: 10.1016/j.biopha.2020.110475. Epub 2020 Jul 9.
Damaged lesion remedial is a devastating impediment of diabetes that escorts to noteworthy disease state, predominantly bottom end diseases. Herbal outputs have exposed to be effectual in managing skin abrasions. Kirenol is recognized to encourage angiogenesis, fibroblast propagation, and exposure of cytokines and development factors concerned in wound remedial. The current study is executed to appraise the wound curing action of kirenol in streptozotocin-persusded diabetic rats by macroscopic parameters, histopathological, enzymatic, and biomolecular methods. Proportion of injure disclosure and reduction was augmented in the kirenol managed group. Histopathological examination exposed declined inflammatory cell applicability and amplified production of fibroblasts, new blood vessels, and displacement of collagen subsequent to kirenol treatment. RT-PCR study displayed diminished concentration of NF-κB, COX-2, iNOS, MMP-2 and MMP-9 levels in reply to kirenol. In accordance with all above findings our present study indicates that kirenol upholds wound medicinal prospective in hyperglycemic circumstances and might be constructive as a dealing and management for unceasing lesions in diabetic patients.
损伤病变的修复是糖尿病的一个毁灭性障碍，会导致严重的疾病状态，主要是末端疾病。草药产品已被证明在处理皮肤擦伤方面有效。基伦醇被认为能促进血管生成、成纤维细胞增殖以及细胞因子和与伤口修复相关的生长因子的暴露。本研究旨在通过宏观参数、组织病理学、酶学和生物分子方法评估基伦醇在链脲佐菌素诱导的糖尿病大鼠中的伤口愈合作用。在基伦醇处理组中，伤口暴露比例和减少比例增加。组织病理学检查显示，炎症细胞浸润减少，成纤维细胞、新血管生成和胶原移位增加，这是基伦醇治疗后的结果。RT-PCR 研究显示，NF-κB、COX-2、iNOS、MMP-2 和 MMP-9 的浓度在基伦醇作用下降低。根据上述所有发现，本研究表明基伦醇支持高血糖环境下的伤口愈合潜力，可能有助于治疗和管理糖尿病患者的慢性病变。
