Lolachi Sanaz, Morin Sarah, Coen Matteo, Samii Kaveh, Calmy Alexandra, Serratrice Jacques
Division of General Internal Medicine, Department of Medicine.
Hematology Division, Department of Oncology, Geneva University Hospitals.
Medicine (Baltimore). 2020 Aug 7;99(32):e21570. doi: 10.1097/MD.0000000000021570.
Macrophage activation syndrome (MAS) is a rare life-threatening condition characterized by cytokine-mediated tissue injury and multiorgan dysfunction.
We describe the unique case of young man who developed MAS as the sole manifestation of an otherwise paucisymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Clinical and biological criteria led to the diagnosis of MAS; cytokine profile was highly suggestive reverse transcription polymerase chain reaction for SARS-CoV-2 in nasopharyngeal swabs was negative, but serum anti-SARS-CoV-2 immunoglobulin A and immunoglobulin G resulted positive leading to the diagnosis of SARS-CoV-2 infection.
The patient was treated with empiric antibiotic and hydroxychloroquine.
Clinical improvement ensued. At follow-up, the patient is well.
SARS-CoV-2 infection may trigger develop life-threatening complications, like MAS. This can be independent from coronavirus disease 2019 gravity.
巨噬细胞活化综合征（MAS）是一种罕见的危及生命的疾病，其特征为细胞因子介导的组织损伤和多器官功能障碍。
我们描述了一名年轻男性的独特病例，他将MAS作为症状轻微的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的唯一表现。
临床和生物学标准导致MAS的诊断；细胞因子谱强烈提示鼻咽拭子中SARS-CoV-2的逆转录聚合酶链反应为阴性，但血清抗SARS-CoV-2免疫球蛋白A和免疫球蛋白G呈阳性，从而导致SARS-CoV-2感染的诊断。
患者接受了经验性抗生素和羟氯喹治疗。
临床症状改善。在随访中，患者情况良好。
SARS-CoV-2感染可能引发危及生命的并发症，如MAS。这可能与2019冠状病毒病的严重程度无关。
