Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Crit Care Clin. 2022 Apr;38(2):195-211. doi: 10.1016/j.ccc.2021.11.013.
Sepsis is a heterogenous and imprecise syndrome that includes multiple phenotypes, some of which are amenable to specific therapies. Developing new therapies for sepsis will require focusing on subsets of patients. Key to improving care is evaluating patients for sepsis mimics and treatable diseases whose manifestations lead to a clinical classification of sepsis. Because sepsis is common, it is easy to overlook unusual causes of organ failure and succumb to confirmation bias about the nature of an illness. Careful attention to medical and family histories, focused diagnostic testing, and subspecialty input can help identify potentially treatable diseases masquerading as typical sepsis.
脓毒症是一种异质性和不精确的综合征，包括多种表型，其中一些表型可以通过特定的治疗方法进行治疗。开发脓毒症的新疗法将需要关注患者的亚组。改善脓毒症治疗的关键是评估疑似脓毒症和可治疗疾病的患者，这些疾病的表现导致了脓毒症的临床分类。由于脓毒症很常见，因此很容易忽视导致器官衰竭的不常见原因，并对疾病的性质产生确认偏误。仔细关注病史和家族史、有针对性的诊断测试和专科意见有助于识别可能作为典型脓毒症出现的潜在可治疗疾病。
