Infochemistry Scientific Center of ITMO University, 9, Lomonosova str., Saint Petersburg, 191002, Russia.
Institute of Chemistry, Saint Petersburg State University, 7/9, Universitetskaya Nab., Saint Petersburg, 199034, Russia.
Chemistry. 2020 Dec 15;26(70):16603-16610. doi: 10.1002/chem.202002947. Epub 2020 Nov 19.
In the last two decades, a large number of self-assembled materials were synthesized and they have already found their way into large-scale industry and science. Hydrogen-bond-based supramolecular adducts are found to have unique properties and to be perfect host structures for trapping target molecules or ions. Such chemical systems are believed to resemble living matter and can substitute a living cell in a number of cases. Herein, a report on an organic material based on supramolecular assembly of barbituric acid and melamine is presented. Surprisingly, the structure is found to host and stabilize radicals under mild conditions allowing its use for biological applications. The number of free radicals is found to be easily tuned by changing the pH of the environment and it increases when exposed to light up to a saturation level. We describe a preparation method as well as stability properties of melamine-barbiturate self-assembly, potentiometric titration, and hydrogen ions adsorption data and EPR spectra concerning the composite.
在过去的二十年中，已经合成了大量的自组装材料，并且它们已经在大规模的工业和科学中找到了应用途径。基于氢键的超分子加合物被发现具有独特的性质，并且是捕获目标分子或离子的理想主体结构。这种化学体系被认为类似于生命物质，并且在许多情况下可以替代活细胞。本文报道了一种基于巴比妥酸和三聚氰胺超分子组装的有机材料。令人惊讶的是，该结构在温和条件下被发现可以容纳和稳定自由基，从而允许其用于生物应用。通过改变环境的 pH 值，可以轻松调节自由基的数量，并且当暴露于光下时，自由基的数量会增加至饱和水平。我们描述了三聚氰胺-巴比妥酸盐自组装的制备方法以及稳定性特性、电位滴定、以及关于复合材料的氢离子吸附数据和 EPR 光谱。
