Timralieva Alexandra A, Moskalenko Ivan V, Nesterov Pavel V, Shilovskikh Vladimir V, Novikov Alexander S, Konstantinova Elizaveta A, Kokorin Alexander I, Skorb Ekaterina V
Infochemistry Scientific Center of ITMO University, Lomonosova str. 9, St. Petersburg 191002, Russia.
Physics Department, M. V. Lomonosov Moscow State University, Leninskie Gory 1/2, Moscow 119991, Russia.
ACS Omega. 2023 Feb 22;8(9):8276-8284. doi: 10.1021/acsomega.2c06510. eCollection 2023 Mar 7.
Use of coantioxidant systems is a prospective way to increase the effectiveness of antioxidant species in tissue repair and regeneration. In this paper, we introduce a novel scheme of a reactive oxygen species (ROS) trap and neutralization during self-assembly of supramolecular melamine barbiturate material. The performed reaction chain mimics the biological process of ROS generation in key stages and enables one to obtain stable hydroperoxyl and organic radicals in a melamine barbiturate structure. Melamine barbiturate also neutralizes hydroxyl radicals, and the effectiveness of the radical trap is controlled with ROS scavenger incorporation. The number of radicals dramatically increases during light-inducing and depends on pH. The proposed scheme of the ROS trap and neutralization opens a way to the use of supramolecular assemblies as a component of coantioxidant systems and a source of organic radicals.
使用协同抗氧化系统是提高抗氧化物质在组织修复和再生中有效性的一种前瞻性方法。在本文中，我们介绍了一种在超分子三聚氰胺巴比妥酸盐材料自组装过程中捕获和中和活性氧（ROS）的新方案。所进行的反应链模拟了关键阶段ROS生成的生物学过程，并能够在三聚氰胺巴比妥酸盐结构中获得稳定的氢过氧自由基和有机自由基。三聚氰胺巴比妥酸盐还能中和羟基自由基，并且通过掺入ROS清除剂来控制自由基捕获的有效性。在光诱导过程中自由基的数量显著增加，并且取决于pH值。所提出的ROS捕获和中和方案为将超分子组装体用作协同抗氧化系统的一个组成部分和有机自由基的来源开辟了道路。
