Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Biruni University, Istanbul, Turkey.
J Med Virol. 2021 Mar;93(3):1409-1413. doi: 10.1002/jmv.26409. Epub 2020 Aug 16.
Since December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has given rise to emerging respiratory infections with pandemic diffusion. The vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels participate in various clinical conditions. The main goal of this study was to evaluate if there was any association between the DBP gene polymorphism at rs7041 and rs4588 loci and the prevalence of COVID-19 and its mortality rates caused among populations of 10 countries including Turkey. Positive significant correlations were found between the prevalence (per million) and mortality rates (per million), and GT genotype (P < .05) while there was a negative significant correlation between prevalence (per million) and mortality rates (per million), and TT genotype at rs7041 locus among all populations (P < .05). However, no significant correlation was found at rs4588 locus. GT genotype was found to confer this susceptibility to the populations of Germany, Mexico, Italy, Czech, and Turkey. The variations in the prevalence of COVID-19 and its mortality rates among countries may be explained by Vitamin D metabolism differed by the DBP polymorphisms of rs7041 and rs4588.
自 2019 年 12 月以来，由严重急性呼吸综合征冠状病毒 2 引起的 2019 年冠状病毒病（COVID-19）导致了新兴的呼吸道感染，并具有大流行扩散的特征。维生素 D 结合蛋白（DBP）及其对总维生素 D 代谢物和游离维生素 D 代谢物水平的调节作用，参与了多种临床情况。本研究的主要目的是评估 DBP 基因在 rs7041 和 rs4588 位点的多态性与 COVID-19 的流行及其在包括土耳其在内的 10 个国家人群中的死亡率之间是否存在关联。在所有人群中，rs7041 位点的 GT 基因型与 COVID-19 的流行率（每百万）和死亡率（每百万）呈正显著相关（P<0.05），与 TT 基因型呈负显著相关（P<0.05）。然而，在 rs4588 位点没有发现显著相关性。GT 基因型被发现使德国、墨西哥、意大利、捷克和土耳其等人群易感。COVID-19 的流行率和死亡率在各国之间的差异可能是由 DBP 基因 rs7041 和 rs4588 多态性导致的维生素 D 代谢不同所解释的。
