Department of Bioinformatics, College of Life Sciences, Shanxi Agricultural University, Taigu, China.
Department of Toxicology, Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
J Biochem Mol Toxicol. 2020 Dec;34(12):e22594. doi: 10.1002/jbt.22594. Epub 2020 Aug 8.
The new coronavirus (COVID-19) was first reported in Wuhan in China, on 31 December 2019. COVID-19 is a new virus from the family of coronaviruses that can cause symptoms ranging from a simple cold to pneumonia. The virus is thought to bind to the angiotensin-converting enzyme 2, as a well-known mechanism to enter the cell. It then transfers its DNA to the host in which the virus replicates the DNA. The viral infection leads to severe lack of oxygen, lung oxidative stress because of reactive oxygen species generation, and overactivation of the immune system by activating immune mediators. The purpose of this review is to elaborate on the more precise mechanism(s) to manage the treatment of the disease. Regarding the mechanisms of the virus action, the suggested pharmacological and nutritional regimens have been described.
新型冠状病毒（COVID-19）于 2019 年 12 月 31 日在中国武汉首次报告。COVID-19 是一种来自冠状病毒家族的新型病毒，可引起从普通感冒到肺炎等各种症状。据认为，该病毒与血管紧张素转换酶 2 结合，作为进入细胞的一种众所周知的机制。然后，它将自己的 DNA 转移到病毒复制 DNA 的宿主中。病毒感染导致严重缺氧，由于活性氧的产生导致肺部氧化应激，以及通过激活免疫介质过度激活免疫系统。本综述的目的是详细阐述更精确的机制来管理疾病的治疗。关于病毒作用的机制，已经描述了建议的药理学和营养方案。
