Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Stephanstr. 1A, 04103 Leipzig, Germany; Emotion Neuroimaging Lab, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr. 1A, 04103 Leipzig, Germany; Clinic of Cognitive Neurology, University of Leipzig, Liebigstr. 16, 04103 Leipzig, Germany.
Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Pauwelsstr. 30, 52074 Aachen, Germany; Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Forschungszentrum Jülich, Wilhelm-Johnen-Str., 52428 Jülich, Germany.
Front Neuroendocrinol. 2020 Oct;59:100859. doi: 10.1016/j.yfrne.2020.100859. Epub 2020 Aug 6.
The peripartum period offers a unique opportunity to improve our understanding of how dramatic fluctuations in endogenous ovarian hormones affect the human brain and behavior. This notwithstanding, peripartum depression remains an underdiagnosed and undertreated disorder. Here, we review recent neuroimaging findings with respect to the neuroplastic changes in the maternal brain during pregnancy and the postpartum period. We seek to provide an overview of multimodal neuroimaging designs of current peripartum depression models of hormone withdrawal, changes in monoaminergic signaling, and maladaptive neuroplasticity, which likely lead to the development of a condition that puts the lives of mother and infant at risk. We discuss the need to effectively integrate the available information on psychosocial and neurobiological risk factors contributing to individual vulnerability. Finally, we propose a systematic approach to neuroimaging the peripartum brain that acknowledges important co-morbidities and variation in disease onset.
围产期为我们提供了一个独特的机会，可以深入了解内源性卵巢激素的剧烈波动如何影响人类大脑和行为。尽管如此，围产期抑郁症仍然是一种未被充分诊断和治疗的疾病。在这里，我们回顾了最近关于孕妇期和产后期间母体大脑神经可塑性变化的神经影像学发现。我们试图提供一个关于当前产后抑郁症模型中激素撤退、单胺能信号变化和适应不良神经可塑性的多模态神经影像学设计的概述，这些变化可能导致一种危及母婴生命的疾病的发展。我们讨论了需要有效整合导致个体易感性的社会心理和神经生物学风险因素的现有信息。最后，我们提出了一种系统的方法来对围产期大脑进行神经影像学研究，承认重要的合并症和疾病发病的变化。
