Śląski Uniwersytet Medyczny, Wydział Nauk Medycznych w Katowicach, Katedra Histologii i Embriologii, Zakład Histologii.
Śląski Uniwersytet Medyczny, Wydział Nauk Medycznych w Zabrzu, Katedra i Zakład Anatomii Opisowej i Topograficznej.
Psychiatr Pol. 2020 Apr 30;54(2):209-222. doi: 10.12740/PP/102659.
The vast majority of new neuropeptides feature unique biochemical properties as well as awide spectrum of physiological activity applied in numerous neuronal pathways, including hypothalamus and the limbic system. Special interest should be paid to nesfatin-1 - the relatively recently discovered and still intensively studied regulatory factor and a potential modulator of eating behaviors. New information about it now allows to consider this neuropeptide as a potentially important factor involved in the pathogenesis of many different mental disorders. The considered pharmacomodulation of nesfatinergic signaling may be potentially helpful in the future treatment of some neuropsychiatric and metabolic disorders including anorexia nervosa. Although the results of some basic and clinical tests seem to be promising, all possible applications of the aforementioned neuropeptides, together with their agonists and antagonists still remain in the area of speculation. The intensive search of selective modulators of their known receptors may facilitate the opening of a promising chapter in the eating disorders therapy. This paper provides a review of recent scientific reports regarding the hypothetical role of nesfatin-1 in the neuronal pathways related to pathophysiology of anorexia nervosa.
绝大多数新的神经肽具有独特的生化特性和广泛的生理活性谱，应用于众多神经元途径，包括下丘脑和边缘系统。应该特别关注 nesfatin-1——这是一种相对较新发现并仍在深入研究的调节因子，也是饮食行为的潜在调节剂。关于它的新信息现在使得人们可以将这种神经肽视为许多不同精神障碍发病机制中潜在的重要因素。目前正在对 nesfatin 能信号进行药理学调节，未来可能有助于治疗一些神经精神和代谢障碍，包括神经性厌食症。尽管一些基础和临床测试的结果似乎很有希望，但上述神经肽及其激动剂和拮抗剂的所有可能应用仍然处于推测阶段。对其已知受体的选择性调节剂的深入研究可能有助于在饮食失调症治疗方面开辟一个充满希望的新篇章。本文综述了最近关于 nesfatin-1 在与神经性厌食症病理生理学相关的神经元途径中假设作用的科学报告。
