Damian-Buda Adriana-Cezara, Matei Daniela Maria, Ciobanu Lidia, Damian-Buda Dana-Zamfira, Pop Raluca Maria, Buzoianu Anca Dana, Bocsan Ioana Corina
Pharmacology, Toxicology and Clinical Pharmacology Laboratory, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Department of Internal Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Biomedicines. 2024 Aug 20;12(8):1913. doi: 10.3390/biomedicines12081913.
Nesfatin-1, deriving from a precursor protein, NUCB2, is a newly discovered molecule with anti-apoptotic, anti-inflammatory, antioxidant, and anorexigenic effects. It was initially identified in the central nervous system (CNS) and received increasing interest due to its energy-regulating properties. However, research showed that nesfatin-1 is also expressed in peripheral tissues, including the digestive system. The aim of this review is to give a résumé of the present state of knowledge regarding its structure, immunolocalization, and potential implications in diseases with inflammatory components. The main objective was to focus on its clinical importance as a diagnostic biomarker and potential therapeutic molecule in a variety of disorders, among which digestive disorders were of particular interest. Previous studies have shown that nesfatin-1 regulates the balance between pro- and antioxidant agents, which makes nesfatin-1 a promising therapeutic agent. Further in-depth research regarding the underlying mechanisms of action is needed for a better understanding of its effects.
Nesfatin-1由前体蛋白NUCB2衍生而来，是一种新发现的分子，具有抗凋亡、抗炎、抗氧化和厌食作用。它最初在中枢神经系统（CNS）中被鉴定出来，因其能量调节特性而受到越来越多的关注。然而，研究表明nesfatin-1也在外周组织中表达，包括消化系统。这篇综述的目的是总结目前关于其结构、免疫定位以及在炎症性疾病中的潜在影响的知识现状。主要目标是关注其作为诊断生物标志物和潜在治疗分子在各种疾病中的临床重要性，其中消化系统疾病尤为令人关注。先前的研究表明nesfatin-1调节促氧化剂和抗氧化剂之间的平衡，这使得nesfatin-1成为一种有前景的治疗剂。为了更好地理解其作用，需要对其潜在作用机制进行进一步深入研究。
