Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Trau Quy, Gia Lam, Hanoi, Vietnam.
Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Arch Virol. 2020 Nov;165(11):2487-2493. doi: 10.1007/s00705-020-04763-8. Epub 2020 Aug 9.
Since late 2018, foot-and-mouth disease (FMD) has reemerged and rapidly swept through pig farms in North and Central Vietnam, despite widespread use of commercial FMD vaccines. To investigate the FMD virus (FMDV) strains responsible for the current epidemics, 40 FMDV samples were collected from 17 provinces during November-December 2018, and the VP1 coding genes were sequenced and analyzed. Phylogenetic analysis and sequence comparisons revealed that all of the reemerging Vietnamese FMDVs belonged to the Mya-98 lineage of the O/Southeast Asia topotype (O/SEA/Mya-98) and shared high nucleotide (99.06-100% identity) and amino acid (97.65-100% identity) sequence similarity with each other. The study results suggested that the reemerging FMDVs originated from local Vietnamese strains. Field viruses had different amino acids in the antigenic sites of VP1 when compared to the strains used in the vaccines. The present study provides an important basis for vaccine selection in the battle against FMD in Vietnam.
自 2018 年末以来，尽管广泛使用了商业口蹄疫（FMD）疫苗，但 FMD 仍在越南北部和中部的养猪场重新出现并迅速蔓延。为了调查导致当前疫情的 FMD 病毒（FMDV）株，2018 年 11 月至 12 月期间从 17 个省采集了 40 个 FMDV 样本，并对 VP1 编码基因进行了测序和分析。系统进化分析和序列比较表明，所有重新出现的越南 FMDV 均属于 O/东南亚拓扑型（O/SEA/Mya-98）的 Mya-98 谱系，彼此之间具有高核苷酸（99.06-100%同一性）和氨基酸（97.65-100%同一性）序列相似性。研究结果表明，重新出现的 FMDV 起源于当地的越南毒株。与疫苗中使用的毒株相比，田间病毒在 VP1 的抗原位点具有不同的氨基酸。本研究为越南抗击 FMD 的疫苗选择提供了重要依据。
