The majority of developing countries are facing enormous challenges in implementing sustainable waste electrical and electronic equipment (e-waste) management systems. Informal e-waste management practices in Ghana have become a critical challenge to the government and the various stakeholders owing to its environmental and health impacts. However, the effort to implement e-waste formalization management practices has been threatened with many barriers. This study aims to identify and evaluate barriers and pathways to the implementation of e-waste formalization management systems in Ghana. A three-phase methodology consisting of the Delphi method, the hybrid best-worst method and the fuzzy TOPSIS technique is employed. The first phase involves extensive literature review and the use of the Delphi method to identify barriers, pathways, and data collection for e-waste formalization. In the second phase, the best-worst method was employed to analyze the relative weight and ranking of the barriers. The third phase involves the application of fuzzy TOPSIS to rank and prioritize pathways to e-waste formalization systems. Fuzzy logic was applied to handle the subjectivity of decision-makers' preferences. A sensitivity analysis was carried out to check the robustness of the framework and address any effect of bias. The outcome of the study indicates that economic and financial limitations are the most significant barriers to e-waste formalization. "Setting up resourced environmental government agencies for effective monitoring and auditing at the regional levels for appropriate e-waste management practices" is the most prominent pathway. The present study can potentially inform policy makers to develop systematic and strategic policies for the implementation of e-waste formalization management systems.