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症状性骨关节炎患者疼痛严重程度和常用镇痛治疗对医疗保健的疾病负担:一项西班牙全国性健康调查。

Disease burden on health care by pain severity and usual analgesic treatment in patients with symptomatic osteoarthritis: a Spanish nationwide health survey.

机构信息

Master in Health Assessment and Market Access, Universidad Carlos III, Madrid, Spain.

Health Economics and Outcomes Research Department, Pfizer, SLU, Alcobendas (Madrid), Spain.

出版信息

Expert Rev Pharmacoecon Outcomes Res. 2021 Aug;21(4):711-719. doi: 10.1080/14737167.2020.1807943. Epub 2020 Sep 17.

DOI:10.1080/14737167.2020.1807943
PMID:32772591
Abstract

BACKGROUND

Osteoarthritis (OA) pain is a health care highly demanding and costing condition.

OBJECTIVE

To estimate disease burden on health care in OA in Spain, determining whether burden differs by pain severity and usual analgesic treatment.

METHODS

A cross-sectional design using the 2017-Spanish-National-Health-Survey was used to abstract data of 5,234 adult patients (women 70.8%; 69.9 years) with a self-reported physician OA diagnosis. Patients were assembled according to pain severity (no/mild, moderate, severe) and use of usual analgesia (treated [66.5%]/untreated). Healthcare resource utilization (HRU) and corresponding costs were expressed Per-Patient-Per-Year (PPPY) and adjusted for covariates.

RESULTS

Average (SD) healthcare cost was €2,274 (5,461) PPPY, with costs linked to outpatient medical visits being the major driver; ~43%. Adjusted PPPY medical visits, days of hospitalization, other healthcare visits, and corresponding costs were significantly higher in severe pain OA patients, compared to moderate or mild/no pain regardless of being currently treated with usual analgesics or not (p < 0.001). Treated OA patients showed higher HRU and costs than untreated patients.

CONCLUSIONS

Severity of pain was the main driver of HRU and costs in OA patients from a nationwide representative survey in Spain. These findings seem to be more consistent in treated versus not treated patients with usual analgesics.

摘要

背景

骨关节炎(OA)疼痛是一种医疗需求高且费用高的疾病。

目的

评估 OA 在西班牙的医疗保健负担,确定疼痛严重程度和常用镇痛治疗是否会影响负担。

方法

采用 2017 年西班牙国家健康调查的横断面设计,从 5234 名自报医生诊断为 OA 的成年患者中提取数据(女性 70.8%;69.9 岁)。根据疼痛严重程度(无/轻度、中度、重度)和常用镇痛治疗(治疗[66.5%] /未治疗)对患者进行分组。每患者每年(PPPY)的医疗资源利用(HRU)和相应的成本表示,并进行了协变量调整。

结果

平均(SD)医疗保健费用为 2274 欧元(5461 欧元)PPPY,门诊医疗访问费用是主要驱动因素,占~43%;与中度或轻度/无疼痛相比,重度疼痛 OA 患者调整后的 PPPY 医疗访问、住院天数、其他医疗访问以及相应的成本显著更高,无论是否正在接受常用镇痛治疗(p<0.001)。与未接受治疗的患者相比,接受治疗的 OA 患者的 HRU 和成本更高。

结论

疼痛严重程度是西班牙全国代表性调查中 OA 患者 HRU 和成本的主要驱动因素。这些发现似乎在接受或不接受常用镇痛治疗的患者中更为一致。

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