Health Science Department, Campus de los Jerónimos, Universidad Católica San Antonio de Murcia UCAM, 30107 Murcia, Spain.
Primary Care Research Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain.
Nutrients. 2022 Jun 3;14(11):2340. doi: 10.3390/nu14112340.
Osteoarthritis is a source of chronic pain and disability. Dietary supplements have been shown to be a more secure option than NSAIDS. Particularly, the eggshell membrane has demonstrated efficacy in relieving joint pain and stiffness. A clinical trial was designed in which three groups were assigned to two different doses of this supplement and compared to a placebo control group. The primary outcome variable was knee pain, which was assessed using a visual analogue scale. Secondary outcome variables were knee functional ability, quadriceps muscle strength (assessed by isometric and isokinetic trials), and quality of sleep. All groups showed a significant decrease in pain perception, although maximum values were obtained in the high-dose group. Isokinetic and isometric trials showed a significant increase in strength in the high-dose group. Eggshell membrane showed the potential to reduce pain and stiffness symptomatology. Here, for the first time, two quantitative variables (mobility and strength of knee joint) were used to accurately evaluate changes in the quality of life of subjects affected by knee joint pain. The results of this study indicate a dose-dependent response, which should be taken into account for later use in therapeutics to establish the correct dosage.
骨关节炎是慢性疼痛和残疾的一个来源。膳食补充剂已被证明比 NSAIDs 更安全。特别是蛋壳膜已被证明在缓解关节疼痛和僵硬方面有效。设计了一项临床试验，将三组分配到两种不同剂量的这种补充剂，并与安慰剂对照组进行比较。主要的结果变量是膝关节疼痛，使用视觉模拟量表进行评估。次要结果变量是膝关节功能能力、股四头肌力量（通过等长和等速试验评估）和睡眠质量。所有组都显示出疼痛感知明显下降，尽管高剂量组获得了最大值。等速和等长试验显示高剂量组力量明显增加。蛋壳膜显示出减轻疼痛和僵硬症状的潜力。在这里，首次使用了两个定量变量（膝关节的活动度和力量）来准确评估受膝关节疼痛影响的受试者的生活质量变化。这项研究的结果表明存在剂量依赖性反应，这在以后的治疗中应考虑用于确定正确的剂量。
