Abou-Zeid A A, Shehata Y M
Zentralbl Bakteriol Parasitenkd Infektionskr Hyg. 1977;132(2):97-108. doi: 10.1016/s0044-4057(77)80051-8.
Gentamicin is a new broad-spectrum antibiotic, basic and water-soluble, produced and developed by Schering Corporation-Bloomfield, New Jersey (1967 and 1968). It is produced by Micromonospora purpurea, a member of a genus of microorganisms from which no other antibiotics have been derived. Paper chromatographic techniques showed the components of gentamicin complex designated as C', C'a, and C2. Gentamicins are bactericidal antibiotics, active in vivo in low concentrations against a wide spectrum of both Gram-positive and Gram-negative organisms. Among the responsive Gram-positive groups of microorganisms are Staphylococcus aureus including many resistant penicillinase producing strains and group A betahemolytic Streptococci. Among the clinically more important species of Gram-positive organisms responsive to gentamicin are both indole-positive and indole-negative Proteus, Pseudomonas, Escherichia coli, Aerobacter, Klebsiella, Salmonella, and Shigella. The production of gentamicins was improved by adding cobalt to the growth medium.
庆大霉素是一种新型广谱抗生素，呈碱性且水溶性好，由新泽西州布卢姆菲尔德的先灵葆雅公司（1967年和1968年）生产研发。它由绛红色小单孢菌产生，该菌属于一个尚未从中提取出其他抗生素的微生物属。纸色谱技术显示了庆大霉素复合物的成分，命名为C'、C'a和C2。庆大霉素是杀菌性抗生素，在体内低浓度时就能对多种革兰氏阳性菌和革兰氏阴性菌发挥作用。在对庆大霉素有反应的革兰氏阳性微生物群体中，包括金黄色葡萄球菌（其中有许多产生青霉素酶的耐药菌株）和A组β溶血性链球菌。在临床上对庆大霉素有反应的更重要的革兰氏阳性菌物种中，有吲哚阳性和吲哚阴性的变形杆菌、假单胞菌、大肠杆菌、气杆菌、克雷伯菌、沙门氏菌和志贺氏菌。通过向生长培养基中添加钴，提高了庆大霉素的产量。
