由紫色小单孢菌产生的庆大霉素类抗生素的作用方式。

Mode of action of gentamicin antibiotics produced by Micromonospora purpurea.

作者信息

Abou-Zeid A A, Eissa A I, Salem H M

出版信息

Zentralbl Bakteriol Naturwiss. 1978;133(4):362-8. doi: 10.1016/s0323-6056(78)80054-8.

Abstract

Gentamicin antibiotics were produced fermentatively by Micromonospora purpurea. They were separated into gentamicin C1, C1a and C2 by paper chromatographic technique, using chloroform, methanol, and 17.0% of NH4OH (2: 1: 1 v/v) as developing solvent. The different antibiotics showed variable antimicrobial activities. The gentamicin antibiotics inhibited the biosynthesis of DNA and RNA of the proteins, present in the cells of Staphylococcus aureus.

摘要

庆大霉素类抗生素由紫色小单孢菌通过发酵产生。利用氯仿、甲醇和17.0%的氢氧化铵（2:1:1 v/v）作为展开剂，采用纸色谱技术将它们分离为庆大霉素C1、C1a和C2。不同的抗生素表现出不同的抗菌活性。庆大霉素类抗生素抑制金黄色葡萄球菌细胞中蛋白质的DNA和RNA的生物合成。