Daum S J, Rosi D, Goss W A
J Antibiot (Tokyo). 1977 Jan;30(1):98-105. doi: 10.7164/antibiotics.30.98.
A mutant of Micromonospora purpurea, which produces the gentamicin complex only when 2-deoxystreptamine is added to the fermentation medium, produces a new antibiotic complex, 2-hydroxygentamicin, when streptamine or 2,4,6/3,5-pentahydroxycyclohexanone is added to the fermentation medium. This mutant also produces the gentamicin complex when 2,4/3,5-tetrahydroxycyclohexanone is added to the fermentation medium. The C1 and C2 components of 2-hydroxygentamicin have broad spectrum in vitro antibacterial activity similar to the gentamicin C1 and C2 components, but with greater activity against some gentamicin-resistant strains.
紫色小单孢菌的一个突变体，仅在向发酵培养基中添加2-脱氧链霉胺时才产生庆大霉素复合物，而当向发酵培养基中添加链霉胺或2,4,6/3,5-五羟基环己酮时，会产生一种新的抗生素复合物2-羟基庆大霉素。当向发酵培养基中添加2,4/3,5-四羟基环己酮时，该突变体也会产生庆大霉素复合物。2-羟基庆大霉素的C1和C2组分具有类似于庆大霉素C1和C2组分的广谱体外抗菌活性，但对一些耐庆大霉素菌株具有更强的活性。
