Matsumoto M, Ando M, Ohta Y
Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan.
Toxicol Lett. 1988 Jan;40(1):21-8. doi: 10.1016/0378-4274(88)90179-8.
Recently, monochlorodibenzofuran, which is formed by the reaction of dibenzofuran with residual chlorine, has been detected in tap water in one region of Japan. The mutagenicities of 1-, 2-, 3-, and 4-chlorodibenzofuran were tested using Salmonella typhimurium TA98 and TA100. 1-Chlorodibenzofuran and 4-chlorodibenzofuran proved to be practically non-mutagenic, while 2-chlorodibenzofuran was weakly mutagenic. Unlike these three isomers, 3-chlorodibenzofuran was markedly mutagenic, and the intensity of its mutagenicity in TA98 was about one-fifth and in TA100 about one-twentieth of that of benzo[a]pyrene.
