3-硝基二苯并呋喃和3-氨基二苯并呋喃的致突变性。

Mutagenicity of 3-nitrodibenzofuran and 3-aminodibenzofuran.

作者信息

Uno Y, Matsushita H, Uehiro T, Yasuhara A, Morita M

机构信息

Chemistry and Physics Division, National Institute for Environmental Studies, Ibaraki, Japan.

出版信息

Toxicol Lett. 1991 Jan;55(1):31-7. doi: 10.1016/0378-4274(91)90024-z.

DOI:10.1016/0378-4274(91)90024-z

PMID:1998195

Abstract

Mutagenicities of 3-nitrodibenzofuran and 3-aminodibenzofuran were examined using Salmonella typhimurium TA98 and TA100. Strong mutagenicity was found in both compounds. The mutagenic potency of 3-nitrodibenzofuran was approximately 3.5-fold stronger in TA98 and twice stronger in TA100 than that of benzo[a]pyrene. Mutagenicity of 3-aminodibenzofuran was observed under metabolic activation and was 10 times stronger in TA98 and about 5 times stronger in TA100 than that of benzo[a]pyrene.

摘要

利用鼠伤寒沙门氏菌TA98和TA100检测了3-硝基二苯并呋喃和3-氨基二苯并呋喃的诱变性。在这两种化合物中均发现了强诱变性。3-硝基二苯并呋喃在TA98中的诱变效力约为苯并[a]芘的3.5倍，在TA100中则为其两倍。3-氨基二苯并呋喃在代谢活化作用下表现出诱变性，在TA98中的诱变效力是苯并[a]芘的10倍，在TA100中约为其5倍。