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低碳水化合物生酮疗法作为治疗暴食和超加工食品成瘾的代谢疗法。

Low carbohydrate ketogenic therapy as a metabolic treatment for binge eating and ultraprocessed food addiction.

机构信息

Metabolic Psychiatry Clinic, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine.

Department of Human Biology, Stanford University, Stanford, California.

出版信息

Curr Opin Endocrinol Diabetes Obes. 2020 Oct;27(5):275-282. doi: 10.1097/MED.0000000000000571.

Abstract

PURPOSE OF REVIEW

The aim of this study was to highlight the recent advancements and future directions for potential use of a low carbohydrate ketogenic dietary approach to treat binge eating and ultraprocessed food addiction. Herein, we explore proposed mechanisms of why a diet low in refined carbohydrates, processed sugar and higher fat content may be helpful in alleviating symptoms.

RECENT FINDINGS

Emerging evidence suggests there may be a metabolic role in development of maladaptive eating. These findings broaden our understanding of eating psychopathology causes. Ultraprocessed, refined or high glycemic index carbohydrates are a possible trigger mediating neurochemical responses similar to addiction. The carbohydrate-insulin model of obesity supports observations of these foods triggering abnormal blood sugar and insulin spikes subsequently leading to changes in metabolic and neurobiological signaling. This results in overeating symptoms and hunger exacerbation, which differs from observed effects of healthy fat consumption and lack of similar insulin spikes. As supported in recent case series, significantly reducing or abstaining from these addictive-like ultraprocessed foods and highly refined carbohydrates could be considered a treatment approach.

SUMMARY

The current review highlights recent and pertinent evidence with respect to theoretical and practical application of low carbohydrate ketogenic therapeutic approaches for ultraprocessed food addiction and binge eating symptoms. VIDEO ABSTRACT:.

摘要

目的:本研究旨在强调低碳水化合物生酮饮食方法在治疗暴饮暴食和超加工食品成瘾方面的最新进展和未来方向。本文探讨了为什么低精制碳水化合物、加工糖和高脂肪含量的饮食可能有助于缓解症状的潜在机制。

发现:新出现的证据表明,代谢紊乱可能在不良进食行为的发展中起作用。这些发现拓宽了我们对进食心理病理学病因的理解。超加工、精制或高血糖指数的碳水化合物可能是一种触发因素,介导类似于成瘾的神经化学反应。肥胖的碳水化合物-胰岛素模型支持了这些食物引发异常血糖和胰岛素飙升的观察结果,随后导致代谢和神经生物学信号的改变。这导致暴饮暴食症状和饥饿加剧,这与健康脂肪摄入的观察结果不同,也不会出现类似的胰岛素飙升。最近的病例系列研究表明,显著减少或戒除这些类似成瘾的超加工食品和高度精制的碳水化合物可以被视为一种治疗方法。

总结:本综述强调了低碳水化合物生酮治疗方法在超加工食品成瘾和暴饮暴食症状的理论和实际应用方面的最新和相关证据。

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