Mazo Jahinover, Singh Sukhdev, Khan Zohaib, Foster Allison, Komarnitsky Ecaterina, Nagaraj Abhiram, Patel Soham, Kikkeri Vinaya
Department of Radiology, Richmond University Medical Center, New York, NY, USA.
College of Medicine, American University of Antigua, New York, NY, USA.
Case Rep Med. 2020 Jul 30;2020:4812036. doi: 10.1155/2020/4812036. eCollection 2020.
Although severe pneumonia and respiratory compromise have remained the predominant complications of coronavirus disease 19, we are now learning this virus is much more varied in its presentation. In particular, there are increasingly reported cases of thromboembolic events occurring in infected patients. . In this report, we present two patients, both under the age of 40 with known risk factors for venous thromboembolism, who presented with respiratory distress. Both patients were diagnosed with SARS-CoV-2 pneumonia and pulmonary embolism requiring management with anticoagulation. Both patients were discharged after a short course in the hospital.
The discussion of a hypercoagulable state induced by coronavirus disease 19 has been well documented; however, the exact mechanisms remain unknown. We suspect that a prothrombotic inflammatory response provoked by coronavirus disease could be the culprit, acting as an additive effect on middle-aged patients with known risk factors for venous thromboembolism. We recommend clinicians closely monitor those with known risk factors for pulmonary embolism.
尽管重症肺炎和呼吸功能不全仍然是冠状病毒病19的主要并发症,但我们现在了解到这种病毒的表现形式更加多样。特别是,越来越多的报道称感染患者出现血栓栓塞事件。在本报告中,我们介绍了两名年龄均在40岁以下且具有静脉血栓栓塞已知危险因素的患者,他们均表现为呼吸窘迫。两名患者均被诊断为SARS-CoV-2肺炎和肺栓塞,需要进行抗凝治疗。两名患者在住院短疗程后均出院。
关于冠状病毒病19诱发的高凝状态的讨论已有充分记录;然而,确切机制仍不清楚。我们怀疑冠状病毒病引发的促血栓形成炎症反应可能是罪魁祸首,对具有静脉血栓栓塞已知危险因素的中年患者产生叠加效应。我们建议临床医生密切监测具有肺栓塞已知危险因素的患者。