Preechasuk Lukana, Akarasereenont Pravit, Boonrak Ranida, Thamsermsang Onusa, Pratumvinit Busadee, Thongtang Nuntakorn
Siriraj Diabetes Center of Excellence, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Evid Based Complement Alternat Med. 2020 Jul 23;2020:3212546. doi: 10.1155/2020/3212546. eCollection 2020.
(TL) is a commonly used herbal medicine in Thailand and in other Asian countries. TL has been approved as a Thai traditional medicine for detoxifying poisons, and the list of possible adverse effects includes hypoglycemia. TL showed hypoglycemic effect in animals possibly due to antioxidant effect and beta-cell preservation. However, the safety of TL herbal tea and its effects on glucose homeostasis have never been investigated in humans.
Twenty healthy volunteers (10 men and 10 women) drank TL herbal tea 3 times/day for 2 weeks. Ten subjects took TL herbal tea 9 grams daily. After the safety of TL herbal tea was established, 10 more subjects took TL 12 grams daily. Clinical and biochemical tests were assessed at baseline and at 2 weeks.
Mean age was 34.9 ± 10.2 years, and mean body mass index was 27.5 ± 5.8 kg/m. Baseline and posttreatment plasma concentrations were as follows: fasting plasma glucose (89 ± 6 vs. 89 ± 7 mg/dL), fructosamine (213 ± 32 vs. 212 ± 33 mol/L), fasting insulin (8.8 [IQR: 5.9-18.4] vs. 10.4 [IQR: 7.4-15.2] U/mL), HOMA-B (101.6 [IQR: 82.3-189.8] vs. 120.4 [IQR: 93.2-153.2]), and HOMA-IR (1.1 [IQR: 0.8-2.3] vs. 1.4 [IQR: 0.9-2.0]), all respectively. There were no significant changes in these parameters, including body weight, blood pressure, lipid profile, and C-reactive protein. No serious adverse events were observed during the study period.
TL herbal tea at doses of 9 and 12 grams daily had good tolerability without any significant adverse effects on fasting plasma glucose level or other glucose homeostasis parameters measured.
（TL）是泰国和其他亚洲国家常用的草药。TL已被批准为泰国传统的解毒药物，其可能的不良反应包括低血糖。TL在动物中显示出降血糖作用，可能是由于抗氧化作用和β细胞保护。然而，TL凉茶的安全性及其对葡萄糖稳态的影响从未在人体中进行过研究。
20名健康志愿者（10名男性和10名女性）每天饮用TL凉茶3次，持续2周。10名受试者每天饮用9克TL凉茶。在确定TL凉茶的安全性后，又有10名受试者每天服用12克TL。在基线和2周时进行临床和生化测试。
平均年龄为34.9±10.2岁，平均体重指数为27.5±5.8kg/m。基线和治疗后血浆浓度如下：空腹血糖（89±6对89±7mg/dL）、果糖胺（213±32对212±33μmol/L）、空腹胰岛素（分别为8.8[四分位距：5.9 - 18.4]对10.4[四分位距：7.4 - 15.2]U/mL）、HOMA - B（101.6[四分位距：82.3 - 189.8]对(120.4[四分位距：93.2 - 153.2])）和HOMA - IR（1.1[四分位距：0.8 - 2.3]对1.4[四分位距：0.9 - 2.0]）。这些参数包括体重、血压、血脂谱和C反应蛋白均无显著变化。在研究期间未观察到严重不良事件。
每天服用9克和12克剂量的TL凉茶耐受性良好，对空腹血糖水平或其他测量的葡萄糖稳态参数没有任何显著不良影响。
