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[卡波西肉瘤与多发性骨髓瘤之间的关联:是由人疱疹病毒8型引起的吗?]

[IAssociation between Kaposi´s sarcoma and multiple myeloma: is it caused by HHV-8?].

作者信息

Kahouli Sophia, Zahid Hafid, Benkirane Majid, Messaoudi Nezha

机构信息

Laboratoire de Recherche et d´Analyses Médicales de la Fraternelle de la Gendarmerie Royale, Rabat, Maroc.

Faculté de Médecine et de Pharmacie de Rabat, Rabat, Maroc.

出版信息

Pan Afr Med J. 2020 Jun 12;36:85. doi: 10.11604/pamj.2020.36.85.22407. eCollection 2020.

Abstract

Kaposi´s sarcoma is a tumor characterized by purple or brownish lesions affecting the skin. It is most commonly associated with human herpes virus type 8 (HHV-8) infection and may be secondary to malignant hemopathy, including lymphomas. We here report a new case of a very rare combination: Kaposi´s disease-multiple myeloma. The study involved Mr. aged 67 years, treated for Kaposi´s disease in the Department of Dermatology. Serological test for HHV-8 was positive; it was associated with stage I multiple myeloma IgG Lambda with a poor prognosis. We here report this 21 case of Kaposi-Kahler in order to highlight Kaposi-human herpes 8 virus variant involved in the pathophysiology of multiple myeloma. More studies are needed in order to establish this exceptional link.

摘要

卡波西肉瘤是一种以影响皮肤的紫色或褐色病变为特征的肿瘤。它最常与8型人类疱疹病毒(HHV-8)感染相关,也可能继发于包括淋巴瘤在内的恶性血液病。我们在此报告一例非常罕见的组合病例:卡波西病-多发性骨髓瘤。该研究涉及一名67岁男性,他在皮肤科接受了卡波西病治疗。HHV-8血清学检测呈阳性;它与预后不良的Ⅰ期多发性骨髓瘤IgG Lambda相关。我们在此报告这例卡波西-卡勒病例,以强调参与多发性骨髓瘤病理生理学的卡波西-人类疱疹8病毒变体。为了确立这种特殊联系,还需要更多的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1ea/7392862/1a29a712a7ab/PAMJ-36-85-g001.jpg

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