Department of Pathophysiology, College of Basic Medicine, Jiamusi University, Jiamusi, China.
Department of Physiology, College of Basic Medicine, Jiamusi University, Jiamusi, China.
Biomed Res Int. 2020 Jul 25;2020:7136075. doi: 10.1155/2020/7136075. eCollection 2020.
Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. . This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of . through its antioxidant effects by using the Open Targets Platform (OTP) website. . The OTP website version of 19.11 was accessed in December 2019 to identify the studies in DCM involving . . . Among the 157 cell targets associated with DCM, the mammalian target of rapamycin (mTOR) was shared by all evidence, drug, and text mining data with 0.08 score association. mTOR also had the highest score association 0.1 with autophagy in DCM. Among the 1731 studies of indexed PubMed articles on published between 1985 and 2019, 33 addressed the antioxidant effects of and its molecular signal pathways involving oxidative stress and therefore were included in the current work. . mTOR is one of the targets by DCM and can be inhibited by the antioxidative properties of directly via scavenging radicals and indirectly via modulating mTOR signal pathways such as Wnt signaling pathway, Erk1/2 signaling, and NF-B pathways.
尽管心血管治疗取得了重大进展，但糖尿病心肌病（DCM）的发病率和死亡率仍在持续上升。因此，迫切需要一种可行的治疗方法。本研究旨在通过使用 Open Targets Platform（OTP）网站，系统地回顾文献并确定 DCM 中的细胞靶点，探讨 通过其抗氧化作用对 DCM 的可能保护作用。2019 年 12 月，通过访问 OTP 网站版本 19.11，确定了涉及 的 DCM 研究。在与 DCM 相关的 157 个细胞靶点中，雷帕霉素靶蛋白（mTOR）是所有证据、药物和文本挖掘数据共有的靶点，其关联分数为 0.08。mTOR 与 DCM 中的自噬也有最高的 0.1 关联分数。在 1985 年至 2019 年间发表的 1731 篇索引 PubMed 文章中，有 33 篇文章探讨了 的抗氧化作用及其涉及氧化应激的分子信号通路，因此被纳入本研究。mTOR 是 DCM 的靶点之一，可通过直接清除自由基和间接调节 mTOR 信号通路（如 Wnt 信号通路、Erk1/2 信号通路和 NF-B 通路）来发挥抗氧化特性。
