遗忘型轻度认知障碍男性与女性患者的比较：海马体过度活跃与模式分离记忆表现
Comparison of male and female patients with amnestic mild cognitive impairment: Hippocampal hyperactivity and pattern separation memory performance.
作者信息
Corona-Long Caitlin A, Tran Tammy T, Chang Elizabeth, Speck Caroline L, Gallagher Michela, Bakker Arnold
机构信息
Department of Psychological and Brain Sciences Johns Hopkins University School of Arts and Sciences Baltimore Maryland USA.
Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA.
出版信息
Alzheimers Dement (Amst). 2020 Aug 3;12(1):e12043. doi: 10.1002/dad2.12043. eCollection 2020.
INTRODUCTION
Recent studies have suggested that sex confers a differential risk in the incidence and prevalence of Alzheimer's disease (AD) thought to be the result of the increased lifespan of women compared to men. However, other factors may contribute to risk beyond the effect of increased lifespan.
METHODS
This study examined the role of sex in hippocampal hyperactivity localized to the dentate gyrus (DG)/CA3 subregion of the hippocampus and associated episodic memory impairment, considered a characteristic feature of AD in patients with amnestic mild cognitive impairment (aMCI).
RESULTS
While participants with aMCI showed decreased memory performance and increased activation in the DG/CA3 when compared to controls, no significant sex-related differences in performance or activation were observed.
DISCUSSION
Although other factors may contribute to sex differences in the prevalence of AD these findings show that no sex differences are observed in hippocampal dysfunction characteristic of the aMCI phase of AD.
引言
近期研究表明，性别在阿尔茨海默病（AD）的发病率和患病率方面存在差异风险，这被认为是女性比男性寿命延长的结果。然而，除了寿命延长的影响外，其他因素可能也会导致风险增加。
方法
本研究调查了性别在海马齿状回（DG）/海马CA3亚区局部海马体过度活跃以及相关情景记忆障碍中的作用，这些被认为是遗忘型轻度认知障碍（aMCI）患者AD的特征。
结果
与对照组相比，aMCI参与者的记忆表现下降，DG/CA3激活增加，但在表现或激活方面未观察到显著的性别相关差异。
讨论
尽管其他因素可能导致AD患病率的性别差异，但这些发现表明，在AD的aMCI阶段特征性的海马功能障碍中未观察到性别差异。
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