在人生长激素生产过程中能否降低克雅氏病感染性的潜在危害？用羊瘙痒病263K毒株进行的灭活实验。快速通讯
Can potential hazard of Creutzfeldt-Jakob disease infectivity be reduced in the production of human growth hormone? Inactivation experiments with the 263K strain of scrapie. Rapid communication.
作者信息
Pocchiari M, Macchi G, Peano S, Conz A
机构信息
Istituto di Neurologia, Universitá Cattolica S. Cuore, Rome, Italy.
出版信息
Arch Virol. 1988;98(1-2):131-5. doi: 10.1007/BF01321014.
PMID:3277594
Abstract
Scrapie infectivity is reduced 5-6 logs following filtration through 100,000 MW cut-off filter plus overnight treatment with 6 M urea. These steps, applied to purified human Growth Hormone (hGH), increase the margin of safety of hGH.
摘要
经100,000分子量截留滤器过滤并经6M尿素过夜处理后，羊瘙痒病感染性降低5至6个对数级。这些步骤应用于纯化的人生长激素（hGH）时，可提高hGH的安全性。
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