胰岛素对脑微血管的作用；对碱性磷酸酶的影响。

Insulin action on brain microvessels; effect on alkaline phosphatase.

作者信息

Catalán R E, Martínez A M, Aragonés M D, Miguel B G, Robles A

机构信息

Departamento de Bioquímica y Biología Molecular, Centro de Biología Molecular (CSIC-UAM), Universidad Autónoma de Madrid, Spain.

出版信息

Biochem Biophys Res Commun. 1988 Jan 29;150(2):583-90. doi: 10.1016/0006-291x(88)90433-0.

DOI:10.1016/0006-291x(88)90433-0

PMID:3277629

Abstract

The effects of insulin on brain alkaline phosphatase activity have been examined. Insulin inhibited the activity of alkaline phosphatase on brain microvessels in in vitro experiments. The inhibition observed was of the non-competitive type. These observations indicate that the hormone is able to induce neurochemical modifications revealed in this case as changes in the phosphate transfer enzymes in brain microvessels.

摘要

已对胰岛素对脑碱性磷酸酶活性的影响进行了研究。在体外实验中，胰岛素抑制了脑微血管中碱性磷酸酶的活性。观察到的抑制作用属于非竞争性类型。这些观察结果表明，该激素能够诱导神经化学变化，在这种情况下表现为脑微血管中磷酸转移酶的变化。