Banks William A
GRECC, Veterans Affairs Medical Center-St. Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 N. Grand Blvd, St. Louis, MO 63106, USA.
Regul Pept. 2008 Aug 7;149(1-3):11-4. doi: 10.1016/j.regpep.2007.08.027. Epub 2008 Apr 7.
The BBB prevents the unrestricted exchange of substances between the central nervous system (CNS) and the blood. The blood-brain barrier (BBB) also conveys information between the CNS and the gastrointestinal (GI) tract through several mechanisms. Here, we review three of those mechanisms. First, the BBB selectively transports some peptides and regulatory proteins in the blood-to-brain or the brain-to-blood direction. The ability of GI hormones to affect functions of the BBB, as illustrated by the ability of insulin to alter the BBB transport of amino acids and drugs, represents a second mechanism. A third mechanism is the ability of GI hormones to affect the secretion by the BBB of substances that themselves affect feeding and appetite, such as nitric oxide and cytokines. By these and other mechanisms, the BBB regulates communications between the CNS and GI tract.
血脑屏障可防止中枢神经系统（CNS）与血液之间物质的无限制交换。血脑屏障（BBB）还通过多种机制在中枢神经系统与胃肠道（GI）之间传递信息。在此，我们综述其中三种机制。首先，血脑屏障在血液至脑或脑至血液的方向上选择性地转运一些肽和调节蛋白。胃肠道激素影响血脑屏障功能的能力，如胰岛素改变血脑屏障对氨基酸和药物的转运能力，代表了第二种机制。第三种机制是胃肠道激素影响血脑屏障分泌自身影响进食和食欲的物质的能力，如一氧化氮和细胞因子。通过这些及其他机制，血脑屏障调节中枢神经系统与胃肠道之间的通讯。
