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Prostate cancer mortality projections reach a new high: With prostate cancer deaths projected to rise to their highest level in 20 years, some experts worry that changes to screening guidelines made in 2012 could be a factor.

作者信息

Printz Carrie

出版信息

Cancer. 2020 Sep 1;126(17):3893-3894. doi: 10.1002/cncr.33127.

DOI:10.1002/cncr.33127
PMID:32776531
Abstract
摘要

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1
Prostate cancer mortality projections reach a new high: With prostate cancer deaths projected to rise to their highest level in 20 years, some experts worry that changes to screening guidelines made in 2012 could be a factor.前列腺癌死亡率预测达到新高：预计前列腺癌死亡人数将升至20年来的最高水平，一些专家担心2012年筛查指南的改变可能是一个因素。
Cancer. 2020 Sep 1;126(17):3893-3894. doi: 10.1002/cncr.33127.
2
New recommendations in prostate cancer screening and treatment.前列腺癌筛查与治疗的新建议。
JAAPA. 2014 Aug;27(8):14-20; quiz 26. doi: 10.1097/01.JAA.0000451872.86566.bf.
3
The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial: the prostate cancer screening results in context.《前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验：从上下文角度看前列腺癌筛查结果》。
Acta Oncol. 2011 Jun;50 Suppl 1:12-7. doi: 10.3109/0284186X.2010.531283.
4
Prognostic Significance of Digital Rectal Examination and Prostate Specific Antigen in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Arm.数字直肠检查和前列腺特异性抗原在前列腺、肺、结直肠和卵巢（PLCO）癌症筛查中的预后意义。
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5
Screening for cancer: lessons learned from the prostate, lung, colorectal, and ovarian cancer screening trial.癌症筛查：从前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中吸取的教训。
Eur Urol. 2015 Oct;68(4):545-6. doi: 10.1016/j.eururo.2015.04.026. Epub 2015 May 8.
6
Prostate-specific antigen velocity based risk-adapted discontinuation of prostate cancer screening in elderly men.基于前列腺特异性抗原速度的老年男性前列腺癌筛查风险适应性终止。
BJU Int. 2011 Jul;108(1):44-8. doi: 10.1111/j.1464-410X.2010.09812.x. Epub 2010 Nov 2.
7
To screen or not to screen: US Preventive Services Task Force's draft guidelines add to prostate cancer screening debate.筛查与否：美国预防服务工作组的指南草案加剧了前列腺癌筛查的争论。
Cancer. 2012 Apr 15;118(8):1959-61. doi: 10.1002/cncr.27559.
8
The Melbourne Consensus Statement on the early detection of prostate cancer.《墨尔本前列腺癌早期检测共识声明》。
BJU Int. 2014 Feb;113(2):186-8. doi: 10.1111/bju.12556.
9
Two large trials show prostate screening has limited reduction in mortality.两项大型试验表明，前列腺筛查在降低死亡率方面作用有限。
Cancer. 2012 Apr 15;118(8):1960. doi: 10.1002/cncr.27560.
10
Biopsy undergrading in men with Gleason score 6 and fatal prostate cancer in the European Randomized study of Screening for Prostate Cancer Rotterdam.在欧洲前列腺癌筛查随机研究（鹿特丹）中，Gleason评分为6分的男性患者活检分级过低与致命性前列腺癌的关系
Int J Urol. 2017 Apr;24(4):281-286. doi: 10.1111/iju.13294. Epub 2017 Feb 7.

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微小 RNA miR-145-5p 通过抑制磷酸脂酶 D5（PLD5）下调细胞增殖和转移，从而减轻前列腺癌。
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Standing Variations Modeling Captures Inter-Individual Heterogeneity in a Deterministic Model of Prostate Cancer Response to Combination Therapy.站立变异建模在前列腺癌联合治疗反应的确定性模型中捕捉个体间异质性。
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