Monaghan M J, Quigley P J, Metcalfe J M, Thomas S D, Jewitt D E
Department of Cardiology, King's College Hospital, London.
Br Heart J. 1988 Jan;59(1):12-9. doi: 10.1136/hrt.59.1.12.
The potential of contrast enhanced digital subtraction echocardiography to demonstrate and quantitate myocardial perfusion was evaluated in 36 patients undergoing routine coronary arteriography or angioplasty. In 24 technically successful studies, multiple cross sectional echocardiographic images, obtained before and after intracoronary (sonicated contrast) injection, were stored by high speed, real time data transfer to an on line minicomputer. Subsequent digital subtraction processing of the stored image data provided composite images in which the distribution of myocardial perfusion was easily seen. Quantitative analysis of peak enhanced myocardial grey level and washout half time successfully differentiated between myocardial segments in which angiography had suggested normal, reduced, and grossly impaired or absent perfusion. The results suggest that this new method of digital image capture and quantitative processing has substantial advantages over previous off line qualitative techniques. It is likely to be of considerable value for routine coronary arteriography, angioplasty, and coronary thrombolysis.
对36例行常规冠状动脉造影或血管成形术的患者，评估了对比增强数字减影超声心动图显示和定量心肌灌注的潜力。在24项技术成功的研究中，冠状动脉内（超声处理的造影剂）注射前后获得的多个横截面超声心动图图像，通过高速实时数据传输存储到在线小型计算机中。随后对存储的图像数据进行数字减法处理，得到了能清晰显示心肌灌注分布的复合图像。对心肌峰值增强灰度和洗脱半衰期的定量分析成功区分了血管造影显示灌注正常、减少、严重受损或无灌注的心肌节段。结果表明，这种数字图像采集和定量处理的新方法比以前的离线定性技术具有显著优势。它可能对常规冠状动脉造影、血管成形术和冠状动脉溶栓具有重要价值。
