Zhang Liqin, Zhang Lihua, Wang Zhangwei, Zhu Lingling, Wang Hongxing, Chen Honghui, Zhang Haibo
Department of Nursing, Nantong Maternity and Child Health Hospital, Nantong University, Jiangsu Province, China.
The Fifth Ward of the Third People's Hospital Affiliated to Nantong University, Jiangsu Province, China.
J Int Med Res. 2020 Aug;48(8):300060520934633. doi: 10.1177/0300060520934633.
This study aimed to investigate application of the urine albumin-to-creatinine ratio (ACR), serum beta 2-microglobulin (β2-MG), and cystatin C as risk markers in a cohort of women with polycystic ovary syndrome (PCOS) for the incidence of gestational diabetes mellitus (GDM).
In this cross-sectional study, we analyzed 312 pregnant women with PCOS and classified them as those with and without GDM. For all participants, elbow venous blood and clean middle urine were collected in the morning after 8 hours of an empty stomach.
Logistic regression analysis showed that the ACR, urine β2-MG levels, and serum cystatin C levels were important markers for women with PCOS concomitant with GDM. Receiver operating characteristic curve analysis showed that the area under the curve of CysC was 0.81 with the threshold based on >0.93 and that of β2-MG was 0.72 with the threshold based on >1.25.
Increased levels of β2-MG and cystatin C and a high ACR might be risk factors for Chinese women with PCOS and GDM during mid-pregnancy.
本研究旨在探讨尿白蛋白与肌酐比值（ACR）、血清β2-微球蛋白（β2-MG）和胱抑素C作为多囊卵巢综合征（PCOS）女性队列中妊娠期糖尿病（GDM）发病风险标志物的应用。
在这项横断面研究中，我们分析了312例患有PCOS的孕妇，并将她们分为患有和未患有GDM的两组。对于所有参与者，在空腹8小时后的早晨采集肘静脉血和清洁中段尿。
逻辑回归分析表明，ACR、尿β2-MG水平和血清胱抑素C水平是患有PCOS合并GDM女性的重要标志物。受试者工作特征曲线分析表明，CysC的曲线下面积为0.81，阈值基于>0.93，β2-MG的曲线下面积为0.72，阈值基于>1.25。
β2-MG和胱抑素C水平升高以及高ACR可能是中国PCOS合并GDM女性孕中期的危险因素。
