Loaiza-Betancur Andrés F, Chulvi-Medrano Iván
University of Antioquia, Medellín, Colombia.
UIRFIDE (Sport Performance and Physical Fitness Research Group), Department of Physical and Sports Education, Faculty of Physical Activity and Sport Sciences, Valencia, Spain.
Sports Health. 2020 Sep/Oct;12(5):470-477. doi: 10.1177/1941738120943882. Epub 2020 Aug 10.
High blood pressure is one of the leading preventable causes of cardiovascular death worldwide. In this regard, several studies have shown interest in the benefits of isometric exercise on blood pressure regulation.
To assess whether low-intensity isometric handgrip exercise (LI-IHE) is an effective strategy to lower blood pressure levels in prehypertensive and hypertensive patients.
This study was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and registered with PROSPERO. Potentially eligible studies were identified after a systematic search conducted on 4 international databases: PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), PEDro, and SPORTDiscus.
We included randomized controlled trials that comprised patients who received LI-IHE.
Systematic review with meta-analysis.
Level 3.
Data related to patient characteristics, exercise programs, risk-of-bias assessment, and outcomes of interest were systematically reviewed independently by 2 authors.
The following reductions (mean differences) were observed after LI-IHE: systolic blood pressure (SBP), (MD) = -5.43 mm Hg; (95% CI, -8.47 to -2.39; = 0.0005); diastolic blood pressure (DBP), -2.41 mm Hg (95% CI, -4.33 to -0.48; = 0.01); mean arterial pressure (MAP), -1.28 mm Hg (95% CI, -2.99 to 0.44; = 0.14).
LI-IHE seems to lower SBP, DBP, and MAP values in prehypertensive and hypertensive adults. It appears that LI-IHE reduces, in greater magnitude, blood pressure levels in hypertensive patients, specifically in patients aged <45 years, those who are overweight, and those on medications. Nevertheless, substantial heterogeneity in the main results and in the analyses by subgroups generated uncertainty about the real reduction magnitude that LI-IHE can produce on blood pressure.
高血压是全球心血管疾病死亡的主要可预防原因之一。在这方面，多项研究已关注到等长运动对血压调节的益处。
评估低强度等长握力运动（LI-IHE）是否是降低高血压前期和高血压患者血压水平的有效策略。
本研究按照PRISMA（系统评价和Meta分析的首选报告项目）声明进行，并在PROSPERO注册。在对4个国际数据库进行系统检索后，确定了潜在符合条件的研究：PubMed、Cochrane对照试验中心注册库（CENTRAL）、PEDro和SPORTDiscus。
我们纳入了包含接受LI-IHE患者的随机对照试验。
系统评价与Meta分析。
3级。
2位作者独立系统地审查了与患者特征、运动方案、偏倚风险评估和感兴趣的结局相关的数据。
LI-IHE后观察到以下血压降低情况（平均差值）：收缩压（SBP），（MD）=-5.43 mmHg；（95%CI，-8.47至-2.39；P = 0.0005）；舒张压（DBP），-2.41 mmHg（95%CI，-4.33至-0.48；P = 0.01）；平均动脉压（MAP），-1.28 mmHg（95%CI，-2.99至0.44；P = 0.14）。
LI-IHE似乎能降低高血压前期和高血压成年人的SBP、DBP和MAP值。LI-IHE似乎能更大程度地降低高血压患者的血压水平，特别是年龄<45岁、超重以及正在服药的患者。然而，主要结果和亚组分析中存在的实质性异质性，使得LI-IHE对血压实际降低幅度产生了不确定性。
