Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Av. Princesa Isabel, 395 Santana, Porto Alegre, RS, 90620-001, Brazil.
Syst Rev. 2022 May 20;11(1):100. doi: 10.1186/s13643-022-01974-9.
Systemic arterial hypertension (HTN) is the leading risk factor of cardiovascular disease death. Lifestyle changes are key for the prevention and management of HTN. Regular aerobic exercise training is recommended as part of the management of HTN, and dynamic resistance exercise should be prescribed as an adjuvant to aerobic training. Recent evidence points to the potential benefits of isometric resistance training in reducing blood pressure (BP). Yet, the hypotensive effect of isometric exercise in prehypertensive and hypertensive individuals is not fully understood. Thus, we will examine the effect of isometric exercise in prehypertensive and hypertensive individuals through a systematic review and meta-analysis.
Our systematic review study will include randomized controlled trials (RCTs) selected from the electronic databases MEDLINE (PubMed), Cochrane, LILACS, EMBASE, Web of Science, and PEDro published in English, Spanish, and Portuguese languages. We will follow the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) and PICOS framework. Our search will involve studies with both male and female participants aged 18 years or more diagnosed with prehypertension or HTN performing one session of isometric exercise (acute effect) or isometric exercise training (chronic effect) compared to a control group (no exercise). We will use the Cochrane Risk of Bias 2 (RoB 2) tool to evaluate the quality of the studies and RStudio software (v1.3.959 for Windows) for statistical analyses.
A meta-analysis of a homogeneous sample of prehypertensive and hypertensive individuals involving isometric handgrip exercise alone can further support previous findings and improve our understanding and recommendations for the management of these populations.
PROSPERO CRD42020213081.
全身性动脉高血压（HTN）是心血管疾病死亡的主要风险因素。生活方式的改变是预防和管理 HTN 的关键。有研究建议将定期的有氧运动训练作为 HTN 管理的一部分，同时将动态抗阻运动作为有氧运动的辅助手段进行处方。最近的证据表明，等长抗阻训练在降低血压（BP）方面可能具有潜在益处。然而，等长运动对高血压前期和高血压患者的降压作用尚未完全了解。因此，我们将通过系统评价和荟萃分析来研究等长运动对高血压前期和高血压患者的影响。
我们的系统评价研究将包括从电子数据库 MEDLINE（PubMed）、Cochrane、LILACS、EMBASE、Web of Science 和 PEDro 中筛选出的英文、西班牙文和葡萄牙文发表的随机对照试验（RCTs）。我们将遵循 PRISMA-P（系统评价和荟萃分析报告的首选条目）和 PICOS 框架。我们的检索将涉及研究男性和女性参与者年龄在 18 岁或以上，诊断为高血压前期或 HTN，进行一次等长运动（急性效应）或等长运动训练（慢性效应），与对照组（无运动）进行比较。我们将使用 Cochrane 风险偏倚评估工具 2（RoB 2）评估研究质量，并使用 RStudio 软件（Windows 版 1.3.959）进行统计分析。
对单独进行等长握力运动的高血压前期和高血压患者进行同质样本的荟萃分析，可以进一步支持先前的研究结果，并增进我们对这些人群的管理的理解和建议。
PROSPERO CRD42020213081。
