Department of Gynecology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanchang University, Nanchang, China.
J Physiol Pharmacol. 2020 Apr;71(2). doi: 10.26402/jpp.2020.2.09. Epub 2020 Aug 8.
This study aims to observe the efficacy of supplemented Er-xian decoction combined with acupoint application in treating poor ovarian response (POR). This study was a randomized controlled trial. A total of 80 patients, who were treated in the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2016 to December 2017, were divided into two groups by tables of random numbers: experimental group (n = 40), and control group (n = 40). In the experimental group, patients orally received supplemented Er-xian decoction with acupoint application. In the control group, a Kuntai capsule was administered according to the course of treatment. The therapeutic effects in the two groups were observed and compared. In the experimental group, the total effective rate was 90%, the cure rate was 15% (six patients), the markedly effective rate was 35% (14 patients), the effective rate was 40% (16 patients), and the ineffective rate was 10% (four patients). In the control group, the total effective rate was 50%, the cure rate was 5% (two patients), the markedly effective rate was 15% (six patients), the effective rate was 30% (12 patients), and the ineffective rate was 50% (20 patients). The differences were statistically significant (P > 0.05). Definite efficacy was observed when a poor ovarian response was treated by supplemented Er-xian decoction combined with acupoint application. Improvements in perimenopausal symptoms, menstruation conditions, hormone levels, inhibin B (INHB), and antral follicle count (AFC) were markedly better in the experimental group than in the control group. In addition, the treatment was safe and had few side effects.
本研究旨在观察补肾养血方联合穴位敷贴治疗卵巢储备功能下降（DOR）的疗效。本研究采用随机对照试验方法，选取 2016 年 1 月至 2017 年 12 月江西中医药大学附属医院收治的 80 例 DOR 患者，按随机数字表法分为两组，实验组（n = 40）和对照组（n = 40）。实验组患者口服补肾养血方联合穴位敷贴治疗，对照组患者给予口服坤泰胶囊治疗。观察并比较两组患者的治疗效果。实验组患者总有效率为 90%，治愈率为 15%（6 例），显效率为 35%（14 例），有效率为 40%（16 例），无效率为 10%（4 例）；对照组患者总有效率为 50%，治愈率为 5%（2 例），显效率为 15%（6 例），有效率为 30%（12 例），无效率为 50%（20 例）。两组比较差异有统计学意义（P > 0.05）。补肾养血方联合穴位敷贴治疗 DOR 疗效确切，能明显改善围绝经期症状、月经情况、激素水平、抑制素 B（INHB）和窦卵泡数（AFC），且安全性高，不良反应少。
