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对丁基羟基茴香醚（BHA）、二丁基羟基甲苯（BHT）和乙氧喹（EMQ）进行了致突变性测试。

Butylhydroxyanisol (BHA), butylhydroxytoluene (BHT) and ethoxyquin (EMQ) tested for mutagenicity.

作者信息

Joner P R

出版信息

Acta Vet Scand. 1977;18(2):187-93. doi: 10.1186/BF03548447.

DOI:10.1186/BF03548447
PMID:327771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8377680/
Abstract

The antioxydants butylhydroxyanisol (BHA), butylhydroxytoluene (BHT) and ethoxyquin (EMQ) were tested for mutagenicity in the so-called “Ames test”. The test was performed with and without the addition of microsomal mixed function oxidase system from rat liver. The compounds were found not to be mutagenic in this test. At high concentration of BHA and EMQ toxic effects on the growth of the bacteria were observed.

摘要

抗氧化剂丁基羟基茴香醚（BHA）、丁基羟基甲苯（BHT）和乙氧喹（EMQ）在所谓的“艾姆斯试验”中进行了致突变性测试。该试验在添加和不添加大鼠肝脏微粒体混合功能氧化酶系统的情况下进行。在该试验中发现这些化合物没有致突变性。在高浓度的BHA和EMQ下，观察到对细菌生长的毒性作用。

相似文献

1
Butylhydroxyanisol (BHA), butylhydroxytoluene (BHT) and ethoxyquin (EMQ) tested for mutagenicity.对丁基羟基茴香醚（BHA）、二丁基羟基甲苯（BHT）和乙氧喹（EMQ）进行了致突变性测试。
Acta Vet Scand. 1977;18(2):187-93. doi: 10.1186/BF03548447.
2
[Toxicity of food additives. -III. Inhibition of the respiratory function induced by BHA and BHT on the liver mitochondria of the rat].[食品添加剂的毒性。-III. 丁基羟基茴香醚（BHA）和二丁基羟基甲苯（BHT）对大鼠肝脏线粒体呼吸功能的抑制作用]
Boll Soc Ital Biol Sper. 1975 Nov 30;51(22):1707-11.
3
Enhancement of tumor formation in mouse lung by dietary butylated hydroxytoluene.
Toxicology. 1981;21(2):95-104. doi: 10.1016/0300-483x(81)90120-7.
4
Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin for promotion of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats.丁基羟基茴香醚、丁基羟基甲苯和乙氧喹对N-丁基-N-(4-羟基丁基)亚硝胺引发、单侧输尿管结扎大鼠膀胱致癌作用的剂量依赖性影响。
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[Toxicity of food additives. -IV. Injury of the membrane and oxidation of the hemoglobin induced by monocyclic compounds on erythrocytes from various species of animals. Structure-activity relationship].
Boll Soc Ital Biol Sper. 1975 Nov 30;51(22):1712-5.
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Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene.丁基羟基茴香醚和丁基羟基甲苯的毒理学与生物化学
J Am Oil Chem Soc. 1975 Feb;52(2):59-63. doi: 10.1007/BF02901825.
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Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of gamma-glutamyl transpeptidase-positive foci development in the liver of rats.丁基羟基茴香醚和丁基羟基甲苯对大鼠两阶段膀胱致癌作用的促进活动以及对大鼠肝脏中γ-谷氨酰转肽酶阳性灶发展的抑制作用。
Carcinogenesis. 1983;4(7):895-9. doi: 10.1093/carcin/4.7.895.
8
Butylated hydroxyanisole, butylated hydroxytoluene and tert.-butylhydroquinone are not mutagenic in the Salmonella/microsome assay using new tester strains.在使用新型测试菌株的沙门氏菌/微粒体试验中，丁基羟基茴香醚、丁基羟基甲苯和叔丁基对苯二酚不具有致突变性。
Mutat Res. 1988 Jul;208(3-4):207-11. doi: 10.1016/0165-7992(88)90062-0.
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Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.丁基羟基茴香醚、乙氧喹和对乙酰氨基酚对N-乙基-N-羟乙基亚硝胺引发的大鼠肝脏和肾脏肿瘤性病变诱导的修饰作用。
Carcinogenesis. 1984 Apr;5(4):525-31. doi: 10.1093/carcin/5.4.525.
10
Histologic and autoradiographic studies on the forestomach of hamsters treated with 2-tert-butylated hydroxyanisole, 3-tert-butylated hydroxyanisole, crude butylated hydroxyanisole, or butylated hydroxytoluene.对用2-叔丁基化羟基茴香醚、3-叔丁基化羟基茴香醚、粗制丁基化羟基茴香醚或丁基化羟基甲苯处理的仓鼠前胃进行的组织学和放射自显影研究。
J Natl Cancer Inst. 1986 Jan;76(1):143-9.

引用本文的文献

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Ethoxyquin: An Antioxidant Used in Animal Feed.乙氧喹啉：一种用于动物饲料的抗氧化剂。
Int J Food Sci. 2013;2013:585931. doi: 10.1155/2013/585931. Epub 2013 Apr 30.
2
Butylated hydroxytoluene: tumor-promoting activity in an in vitro two-stage carcinogenesis assay.丁基羟基甲苯：体外两阶段致癌试验中的促癌活性。
Bull Environ Contam Toxicol. 1982 Jul;29(1):115-20. doi: 10.1007/BF01606098.
3
Hepatocellular tumorigenicity of butylated hydroxytoluene administered orally to B6C3F1 mice.对B6C3F1小鼠口服丁基羟基甲苯的肝细胞致瘤性。
Jpn J Cancer Res. 1988 Jan;79(1):49-58. doi: 10.1111/j.1349-7006.1988.tb00010.x.

本文引用的文献

1
Carcinogenicity tests.致癌性试验。
Science. 1976 Jan 23;191(4224):241-5. doi: 10.1126/science.191.4224.241-b.
2
The ames assay.艾姆斯试验
Science. 1976 Jul 23;193(4250):272-4. doi: 10.1126/science.193.4250.272-b.
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Evaluation of short-term tests for carcinogenicity.
Toxicol Appl Pharmacol. 1974 Aug;29(2):157-80. doi: 10.1016/0041-008x(74)90054-4.
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Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.致癌物是诱变剂：一种将用于活化的肝脏匀浆和用于检测的细菌相结合的简单测试系统。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2281-5. doi: 10.1073/pnas.70.8.2281.
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Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.在沙门氏菌/微粒体试验中作为诱变剂的致癌物检测：300种化学物质的测定
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135-9. doi: 10.1073/pnas.72.12.5135.
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Mutat Res. 1976 Aug;38(4):243-58. doi: 10.1016/0165-1161(76)90149-7.
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Short term screening tests for carcinogens.
Nature. 1976 May 20;261(5557):195-200. doi: 10.1038/261195a0.
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Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.用沙门氏菌/哺乳动物微粒体诱变性试验检测致癌物和诱变剂的方法。
Mutat Res. 1975 Dec;31(6):347-64. doi: 10.1016/0165-1161(75)90046-1.