脑脊髓液和血液中氨基酸水平作为帕金森病潜在生物标志物的研究：综述和荟萃分析。

Cerebrospinal and blood levels of amino acids as potential biomarkers for Parkinson's disease: review and meta-analysis.

机构信息

Section of Neurology, Hospital Universitario del Sureste, Madrid, Spain.

UNEx, ARADyAL Instituto de Salud Carlos III, University Institute of Molecular Pathology Biomarkers, Cáceres, Spain.

出版信息

Eur J Neurol. 2020 Nov;27(11):2336-2347. doi: 10.1111/ene.14470. Epub 2020 Sep 11.

DOI:10.1111/ene.14470

PMID:32777152

Abstract

BACKGROUND AND PURPOSE

The present systematic review and meta-analysis aims to establish the possible value of cerebrospinal fluid (CSF) and serum/plasma levels of amino acids as markers of Parkinson's disease (PD).

METHODS

This is a review of four databases (PubMed, Embase, MEDLINE and Web of Science - Core Collection) from 1966 to 14 March 2020, with identification of references of interest for the topic. The meta-analysis of eligible studies was done using R software package meta, following the PRISMA and MOOSE guidelines.

RESULTS

Compared with age- and sex-matched controls, PD patients showed decreased CSF levels of glutamate and taurine and increased CSF levels of tyrosine; decreased serum/plasma levels of aspartate, serine, tryptophan and lysine, and increased serum/plasma proline and homocysteine levels.

CONCLUSION

Despite the limitations of this study due to the important variability of results between different series, our findings suggest the value of CSF or serum/plasma levels of several amino acids in the discrimination of PD patients from healthy subjects, related to the levels of some amino acids.

摘要

背景与目的

本系统评价和荟萃分析旨在确定脑脊液（CSF）和血清/血浆氨基酸水平作为帕金森病（PD）标志物的可能价值。

方法

这是对四个数据库（PubMed、Embase、MEDLINE 和 Web of Science - Core Collection）从 1966 年至 2020 年 3 月 14 日的回顾，对感兴趣的主题的参考文献进行了识别。使用 R 软件包 meta 对符合条件的研究进行荟萃分析，遵循 PRISMA 和 MOOSE 指南。