Ruffin R, Bryant D, Burdon J, Marlin G, Mitchell C, O'Hehir R, Wilson J, Woolcock A, Webb S
Chest. 1988 Mar;93(3):510-4. doi: 10.1378/chest.93.3.510.
We compared the bronchodilating effects of intravenously administered enprofylline (2 mg/kg) with nebulized terbutaline (10 mg) in patients presenting to hospital with acute asthma in a multicenter double-blind parallel study. One hundred twenty three patients were randomized into the study, and 69 of these fulfilled the inclusion criteria and a retrospective time to study entry criterion; 34 received enprofylline and 35 received terbutaline. There was no significant difference in maximum increase in forced expired volume in 1 second (FEV1) between the enprofylline group (0.24 +/- 0.33 L) and the terbutaline group (0.25 +/- 0.28 L) (p greater than 0.05), nor for the increase in FEV1 over the 1-hour study period. Tremor was reported more in the group receiving terbutaline, and nausea was reported more in the group receiving enprofylline. Two patients experienced hypotension and one patient had a vasovagal episode with enprofylline treatment. Both agents acted as bronchodilators with similar efficacy in patients with acute asthma in this study.
在一项多中心双盲平行研究中，我们比较了静脉注射恩丙茶碱（2毫克/千克）与雾化吸入特布他林（10毫克）对因急性哮喘入院患者的支气管扩张作用。123名患者被随机纳入研究，其中69名符合纳入标准及回顾性研究入组时间标准；34名接受恩丙茶碱治疗，35名接受特布他林治疗。恩丙茶碱组一秒用力呼气容积（FEV1）的最大增加值（0.24±0.33升）与特布他林组（0.25±0.28升）之间无显著差异（p＞0.05），在1小时的研究期间FEV1的增加值也无显著差异。报告显示，接受特布他林治疗的组震颤更多见，接受恩丙茶碱治疗的组恶心更多见。恩丙茶碱治疗中有2名患者出现低血压，1名患者发生血管迷走神经发作。在本研究中，两种药物对急性哮喘患者均起到了支气管扩张剂的作用，且疗效相似。
