"Bonomo" Hospital, Andria, Italy.
J Nephrol. 2010 Sep-Oct;23 Suppl 15:S37-40.
A number of structural changes occur in the kidney with aging. The aging kidney is characterized by loss of renal mass, arterial sclerosis, arteriolar hyalinosis, an increased number of sclerotic glomeruli, loss of tubules and interstitial fibrosis. The pathogenesis of aging-associated structural changes is not completely understood. Both genetic background and hemodynamic factors have been associated with progression of age-related morphological changes. The structural changes of aging kidney are nonspecific and can be seen in many conditions, including diabetes and hypertension, and, as such, arterionephrosclerosis of aging is a diagnosis of exclusion.
随着年龄的增长，肾脏会发生一些结构变化。衰老的肾脏的特征是肾质量的丧失、动脉粥样硬化、小动脉玻璃样变性、硬化肾小球数量增加、肾小管和间质纤维化的丧失。衰老相关结构变化的发病机制尚不完全清楚。遗传背景和血液动力学因素都与与年龄相关的形态变化的进展有关。衰老肾脏的结构变化是非特异性的，可在许多情况下看到，包括糖尿病和高血压，因此，衰老性血管肾硬化是一种排除性诊断。
