Epstein M
Fed Proc. 1979 Feb;38(2):168-71.
A host of abnormalities of renal structure and function accompany advancing age. This presentation briefly surveys the renal anatomical and functional changes associated with senescence. Four areas of renal functional change have been selected for in-depth discussion: a) renal blood flow; b) glomerular filtration rate; c) renal sodium handling; and d) renal concentrating ability. The methodologic considerations including population selection which confound the assessment of the effects of aging on renal function are discussed. In addition, the functional changes associated with senescence are discussed in the context of longitudinal studies and studies utilizing appropriate patient cohorts, including potential kidney transplant donors. The clinical implications of senescent changes with regard to adjusting "normative" standards to fit the age of the patient are addressed. Furthermore, the implications of age-related renal functional alterations in predisposing the elderly patient to a number of fluid and electrolyte derangements are considered.--Epstein, M. Effects of aging on the kidney.
随着年龄的增长，会出现一系列肾脏结构和功能异常。本报告简要概述了与衰老相关的肾脏解剖和功能变化。已选择四个肾脏功能变化领域进行深入讨论：a）肾血流量；b）肾小球滤过率；c）肾脏对钠的处理；d）肾脏浓缩能力。讨论了包括人群选择在内的方法学考量因素，这些因素混淆了衰老对肾功能影响的评估。此外，在纵向研究以及利用适当患者队列（包括潜在肾移植供体）的研究背景下，讨论了与衰老相关的功能变化。探讨了衰老变化在调整“正常”标准以适应患者年龄方面的临床意义。此外，还考虑了与年龄相关的肾功能改变使老年患者易发生多种液体和电解质紊乱的影响。——爱泼斯坦，M. 衰老对肾脏的影响
