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应对 COVID-19 的潜在策略。

Potential strategies for combating COVID-19.

机构信息

Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan.

Department of Clinical Sciences, College of Pharmacy, Al-Ain University of Science and Technology, Abu Dhabi, United Arab Emirates.

出版信息

Arch Virol. 2020 Nov;165(11):2419-2438. doi: 10.1007/s00705-020-04768-3. Epub 2020 Aug 10.

Abstract

Coronavirus disease 2019, also known as COVID-19, is caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2. The infection has now catapulted into a full-blown pandemic across the world, which has affected more than 2 million people and has led to approximately 150,000 fatalities all over the world (WHO). In this review, we elaborate all currently available data that shed light on possible methods for treatment of COVID-19, such as antiviral drugs, corticosteroids, convalescent plasma, and potentially effective vaccines. Additionally, ongoing and discontinued clinical trials that have been carried out for validating probable treatments for COVID-19 are discussed. The review also elaborates the prospective approach and the possible advantages of using convalescent plasma and stem cells for the improvement of clinical symptoms and meeting the demand for an instantaneous cure.

摘要

新型冠状病毒病(COVID-19)又称 2019 冠状病毒病,由一种新型冠状病毒引起,这种病毒被命名为严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)。目前,该感染已在全球范围内迅速蔓延,影响了超过 200 万人,并导致全球约 15 万人死亡(世界卫生组织)。在这篇综述中,我们详细阐述了目前所有可用的数据,这些数据为 COVID-19 的治疗方法提供了线索,如抗病毒药物、皮质类固醇、恢复期血浆和可能有效的疫苗。此外,还讨论了正在进行和已停止的临床试验,以验证 COVID-19 的可能治疗方法。该综述还阐述了使用恢复期血浆和干细胞改善临床症状和满足即时治疗需求的潜在方法和可能优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9990/7416802/5f28c2008227/705_2020_4768_Fig1_HTML.jpg

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